Parimal Chandra Sen

Parimal Chandra Sen
NASI Senior Scientist

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Previous appointments:

1978-1980 Post-doctoral Research Fellow, State University of New York, Syracuse, USA
1980-1983 Research Associate, The Hormel Institute, University of Minnesota, Austin, Minnesota, USA

Research interests:

The main research interest is to work on different Biochemical aspects of  various  transport  enzymes e.g. Na+ ,K +-ATPase, Ca2+,Mg 2+-ATPase, Ca2+-ATPase etc and their interactions with different drugs (contraceptive and amphiphilic) and lipids in natural and model membranes; fluorescence behaviour of enzymes and how their function/activity are affected under various experimental (e.g. drug induced) conditions ; mechanism of regulation of transport enzymes by protein kinases, phosphatase, endogenous stimulator and/or inhibitor proteins ( to explore their role in cell regulation and if they have any phamacological importance and to use these modulators as drugs particularly as contraceptive drugs ),  characterization of peptide domain responsible for Ca2+-ATPase and Ca-transport ; determination of amino acid sequence of domain and if possible to clone it and compare the findings with the well known Mg2+, Ca2+-ATPase in order to explore the role of the ATPase  in fertility regulation; regulation of ATPases by synthetic compounds and their possible use as anticancer agent.

 Recently we have oriented our work to some synthetic compounds which are found to regulate different ion transporting enzymes. A  group of compound analog of calcium blockers have been synthesized.  A few of these  compounds named as Nifetepimine, Phemindole, Mephindole are found to be quite effective not only as an inhibitor of SERCA but are found to induce apoptosis in breast cancer cells to a significant level both in vitro and in vivo studies. Due to solubility problem nanoncapsulated approach to suitable vehicles have been used with significant success.


Address: Division of Molecular Medicine
Centenary Campus
Bose Institute
P-1/12 C.I.T. Scheme VII-M
Kolkata - 700054, India
E-Mail: parimal[at]
Phone: +91-33-25693222


Has been working with ion transporting enzymes (Na+,K+-ATPase, Ca2+- and Ca2+,Mg2+-ATPases etc) and their regulation by drugs, endogenous modulator proteins and protein kinase(s) for more than twenty years. He has made significant contribution in the above mentioned area which has been recognised Internationally as evident from publications of International repute.

The mechanism of regulation of ion transporting ATPases by Chloroquine (antimalarial drug) and Chlorpromazine (antipsychotic and antifertility drug) has been established both from in vitro and in vivo studies in different organs of rat.

During the investigation, a novel Mg2+-independent Ca2+-ATPase has been identified in rat and goat testes that has been purified and characterized and is found to take part in Ca2+-transport and Ca2+-pump regulation thus possibly is  involved in fertility regulation.

This Ca2+-ATPase has a lot of similarities with the well known Ca2+,Mg2+-ATPase. From immunocrossreactivity study, it is found that both belong to SERCA (sarcoplasmic-endoplasmic reticulum Ca2+-ATPase) family.

The ATPase activities (Na+,K+-ATPase and Ca2+- and Ca2+,Mg2+-ATPase activities) are found to be regulated by endogenous modulator proteins of varying masses. One, molecular  mass of  13 kDa from rat brain cytosol was found to inhibit Na+,K+-ATPase and the other, a 12 kDa protein from the same source, regulate Ca2+- and Ca2+, Mg2+-ATPases by inhibiting former and stimulating the latter.

Therefore, the 12 kDa modulator is considered to be a specific tool in distinguishing the properties of Ca2+- and Ca2+,Mg2+-ATPase, reported first time from our laboratory. Both of them have been functionally characterized with respect to the regulation of ATPases.

They also inhibit protein phosphorylation by a novel protein kinase ( PKx ) which is activated by arachidonic acid and has been purified and characterized in our laboratory from goat testis.

So these modulator proteins are believed to be involved in various cellular function (through protein phosphorylation) including the regulation of ATPase activities.

The phosphorylation and dephosphorylation steps of Ca2+-ATPase is comparable to Ca2+,Mg2+-ATPase except that in the former case it is controlled by high and low concentration of calcium ion thus further strengthened the support of its involvement in Ca- transport in sperm cells thus fertility regulation like Ca2+,Mg2+-ATPase.

The 12 kDa modulator protein is found to be effective as female anti-fertility agent as evident from experiments with rat and rabbit. An Indian  patent has been awarded on this work.

Based on the above findings and available data, a scheme has been proposed showing the regulation of ion transporting ATPases by drugs, modulator proteins and protein kinase-C.

Recently a group of analogs of calcium blockers have been synthesized and their effects on Ca-ATPase are being investigated. At least one compound, we have named it as Nifetepimine, an analog of nifedipine, Phemindole and Mephindole (indole derivatives)  are found to be quite effective not only as an inhibitor of SERCA but effective to induce apoptosis in breast cancer cells at a significant level. Due to solubility problem nanoncapsulated approach to suitable vehicles have been used with significant success.


1. P.C.Sen, A.Ghosh and J.Datta. Argentation column chromatography: A new ternary solvent system for the separation of methylesters of polyunsaturated fatty acids. J.Chromatogr. 129: 469-470, 1976. 

                   No. of times cited : 4

2. P.C.Sen, A.Ghosh  and J.Datta. Fatty acids of lipids of murrels. J.Sci.Food.Agric. 27: 811-818, 1976. 

                   No. of times cited : 10

3. P.C.Sen, A.Ghosh and J.Datta. Fatty acids of fresh water fish, Featherbacks. J.Ind.Che.Soc. 53:  920-923, 1976.  

                   No. of times cited : 3

4. S.B.Mandal, P.C.Sen and P.Chakrabarti. Effect of respiratory-deficiency and temperature on the mitochondrial lipid metabolism of Aspergillus niger. Can.J.Microbiol. 24: 586-592, 1978.       

                   No of times cited : 16

5. P.C.Sen, S.B.Mandal and P.Chakrabarti. Phylogenetic studies on brain lipids. Ind.J.Exp.Biol. 16: 1042-1046, 1978.

6. M.K.Roy Chowdhury, P.C.Sen, S.B.Mandal and P.Chakrabarti.  Stimulation of B-lactamaseactivity in Escherichia coli. Ind.J. Biochem.Biophys. 15:211-213, 1978.

                            No of times cited : 2

7. P.C.Sen and T.K.Ray. Lipid environment of gastric K-stimulated adenosine triphosphatase. Biochem.J. 182: 637-640, 1979. 

                   No. of times cited : 12

8. P.C.Sen and T.K.Ray. Characterization of gastric mucosal-membranes : I. Lipid composition of purified gastric microsomes from pig, rabbit and frog. Arch. Biochem. Biophys. 198: 548-555, 1979. 

                   No. of times cited : 27

9. P.C.Sen and T.K.Ray. Control of the K-stimulated ATPase of pig gastric microsomes: Effects of lipid environment and the endogenous activator. Arch.Biochem.Biophys. 202: 8-17, 1980. 

                   No. of times cited : 30

10. P.C.Sen and T.K.Ray. Characterization of gastric mucosal membranes : II. Lipid composition of purified gastric mitochondria from pig, rabbit and frog. Biochim.Biophys. Acta, 618: 300-307, 1980       

                   No. of times cited : 6

11. S.B.Mandal, P.C.Sen and P.Chakrabarti. In vitro synthesis of phosphatidylinositol and phosphatidylcholine by phospholipase-D.  Phytochemistry, 19: 1661-1663, 1980.    

                   No of times citd : 17

12. P.C.Sen, L.L.Tague and T.K.Ray. Relationship between H  and K  secretion in bullfrog gastric mucosa : Characterization of the K-conductive pathway. Am.J.Physiol. 239: G485-492, 1980. 

                   No. of times cited : 16

13. P.C.Sen, Zhou Meng Ai and T.K.Ray.  Bi-layer  orientation of  membrane bound NH 

groups across microsomal vesicles and their role in the function of gastric K-stimulated ATPase. Arch.Biochem. Biophys. 205: 340-351, 1980. 

                   No. of times cited : 17

14. T.K.Ray, Zhou Meng Ai and P.C.Sen. Lipid protein interaction in  gastric microsomal membrane and regulation of H,K-ATPase. in Hydrogen Ion Transport in  Epithelia Edt. by I.Schulz et el.  Elsevier/ North Holland Biomedical Press. pp. 203-215, 1980.                

                   No. of times cited : 8

15. T.K.Ray and P.C.Sen. Demonstration and characterization of a Ca-stimulated ATPase activity in purified gastric microsomes after trypsin treatment. Calcium Binding Proteins: Structure and Function. F.L.Siegel, E.Carafoli, H.Kretsinger, D.H.McLennan and R.H.Wasserman. Elsevier/ North Holland Inc. pp.93-96, 1980. 

                   No. of times cited :  5

16. P.C.Sen and T.K.Ray. Distribution of lipid and protein associated amino groups across pig gastric microsomes. Biochem.J. 195: 515-518, 1981.

                   No. of times cited : 5

17. T.K.Ray and P.C.Sen. Trypsinization unmasks a Ca-stimulated ATPase activity from purified pig gastric microsomes. Life Science 28: 1969-1974, 1981.

                   No. of times cited : 9

18. P.C.Sen, J.G.Kapakos and M.Steinberg (Flashner). Modification of Na,K-ATPase :evidence for the involvement of different amino groups at different PH  values. Arch. Biochem. Biophys. 211: 652-661, 1981.

                   No. of times cited :  42

19. J.Nandi, T.K.Ray and P.C.Sen. Studies on gastric Ca-stimulated ATPase : : Characterization and general properties. Biochim.  Biophys.Acta, 646: 457-464, 1981. 

                   No. of times cited : 29

20. P.C.Sen and D.R.Pfeiffer. Characterization of partially purified Na,K-ATPase from porcine lens. Biochim.Biophys.Acta, 693: 34-44, 1982.

                   No. of times cited : 26  

21. M.Steinberg, J.G.Kapakos and  P.C.Sen.  Interaction of divalent cations with fluorescein isothiocyanate labelled  Na,K-ATPase. In “Current Topics in Membrane and  Transport” Vol.19, edt. F.Bronner and A.Kleinzeller, Academic Press, New York.  pp.457-463, 1983.

                    No. of times cited  : 4

22. P.C.Sen and D.R.Pfeiffer. Loss of Na,K-ATPase  activity during cataract formation. In “Current Topics in Membrane and Transport” Vol. 19, edt. F.Bronner and A.Kleinzeller, Academic Press, New York, pp. 959-964, 1983.

                   No. of times cited : 3

23. P.C.Sen and D.R.Pfeiffer. Tissue specific inhibition of ATPase activities by triparanol feeding. Exp.Eye Res. 37: 209-212, 1983.

                   No.  of  times cited : 2

24. P.C.Sen, R.J.Krebsbach and D.R.Pfeiffer. Persistent stimulation of lens fiber cell Na, K-ATPase by sodium thiocyanate. Exp.Eye Res. 43: 315-327, 1986

                   No. of times cited : 10

25. S.Mukherjee, P.Charkrabarti and P.C.Sen. Alteration of lipid composition, Na,K-ATPase,   -3B  hydroxy  steroid  dehydrogenase activities in the microsomal membrane of toad  ovary  in  different seasons. J.Biosc. 12: 249-246,  1987.                

                   No. of times cited : 5

26. S.Mukherjee, B.Mazumder and P.C.Sen. Potassium -ion stimulated ATPase activity in the microsomal membranes of toad gastric mucosa in different seasons. Ind.J.Biochem. Biophys. 24:103-106, 1987.

                   No. of times cited : 2

27. B.Mazumder, S.Mukherjee, S.K.Nagdas and P.C.Sen. The interaction of chloroquine with transport ATPase and acetylcholinesterase in microsomal membranes of rat in vitro and in vivo. Biochem.Int.  16:35-44, 1988.

                   No. of times cited : 17

28. S.Chakrabarty, P.C.Sen and N.K.Sinha. Purification and chracterization of a low molecular weight basic protein from marine turtle egg white. Arch.Biochem.Biophys. 262: 286-292,1988.            

                   No. of times cited : 5

29. S.K.Nagdas, S.Mukherjee, B.Mazumder and P.C.Sen. Identification and characterization of Mg  -dependent and an independent Ca  - ATPase in microsomal membranes of rat testes. Mol.Cell.Biochem.  79: 161-169, 1988.            

                   No. of times cited : 28

30. S.Mukherjee and P.C.Sen. Changes in lipid composition and some biologically important enzyme activities in the microsomal membranes of toad ovary in different seasons. Ind.J.Biochem.Biophys. 26:153- 159, 1989.

31. B.Mazumder, S.Mukherjee and P.C.Sen. The chlorpromazine inhibition of transport ATPase and acetylcholinesterase activities in the microsomal membranes of rat in vitro and in vivo. Mol. Cell. Biochem. 95:13-20, 1990            

                    No of times cited : 22

32. P.C.Sen and E.Racker. Phosphorylation and proteolytic degradation of neurofilaments. Cell. Physiol. Biochem. 1:55-63, 1991.           

                   No. of times cited : 7

33. E. Racker and P.C.Sen. Assay of phosphorylation of small substrates and synthetic random polymers that interact chemically with ATP. Methods in Enzymology, 200:112-114, 1991.         

                   No. of times cited : 4

34. B.Mazumder, R.Sikdar and P.C.Sen. Inhibition of Ca - ATPase by gossypol and chlorpromazine in the microsomal membranes of rat testis. Current Trends in Biomembranes in Health and Diseases. Edt.  by A.M.Kidwai, A.K.Upretiand P.K.Ray. Today and Tomorrow’s Publishers, New Delhi, vol.2,pp.407-412, 1991.

                   No of times cited : 4

35. B.Mazumder, R.Sikdar and P.C.Sen. The effect of chlorpromazine and gossypol on Ca  ATPase activities in the microsomal membranes of testes. Ind.J.Biochem.Biophys. 28:136-139,1991.  

                    No. of times cited : 12

36. R.Sikdar, U.Ganguly, P.Pal, B.Mazumder and P.C.Sen. Biochemical characterization of a Ca - ATPase from goat spermatozoa.  Mol.Cell.Biochem. 103:121-130,1991.

                   No. of times cited : 30   

37. G.Adhikary, S.Chandra, R.Sikdar, P.C.Sen and P.Nandy. The inhibition of transport enzyme activities in different organs of rat by chlorpromazine in vivo is reversible. Biochem.Int.  25:951-961, 1991.               

                   No. of times cited : 9

38. M.R.Mawal, P.C.Sen, M.AbdelGhany, D.Shalloway and E.Racker. Phosphorylation of Tau  by  purified purifie P 34 cdc28  and related protein kinase from neurofilaments. J.Biol.Chem. 267:19705-19709, 1992.            

                   No. of times cited : 65

39. S.Chandra, G.Adhikary, R.Sikdar and P.C.Sen. The in vivo inhibition of transport enzyme activities by chloroquine in different organs of rat is reversible. Mol.Cell. Biochem. 118:15-21, 1992.              

                   No.of times cited : 18

40. R.Sikdar, U.Ganguly, S.Chandra, G.Adhikary and P.C.Sen. Ca - ATPase and Ca  -uptake in goat spermatozoa membranes do not require Mg .  J. Biosc. 18:73-82, 1993

                   No. of times cited : 9

41. A.Ghose Chaudhury, P.C.Sen and U.Ganguly. Evidence for protein kinase C stimulation in rat enterocytes pretreated with heat stable enterotoxin of E.coli (Sta). FEMS Letters. 110:185-190, 1993. 

                   No. of times cited : 12

42. S.Chandra, G.Adhikary, R.Sikdar and P.C.Sen. An Na ,K -ATPase inhibitor protein from rat brain cytosol. Biochim.Biphys.Acta, 1144:33-38, 1993.          

                   No. of times cited : 9

43. D.Ghosal, P.C.Sen and A.K.Barua. Differential effect of bone marrow protein on ATPase of immunized control and malnourished rats. Nutrition. 10: 21-25, 1994.            

                   No. of times cited : 2

44. G.Adhikary, S.Chandra, R.Sikdar and P.C.Sen. The amphiphilic drug induced tryptophan fluorescence change of ion transporting ATPases. Biochim.Biophys.Acta, 1188: 220-226, 1994. 

                             No. of times cited : 3

45. A.Ghose Chaudhuri, P.C.Sen and U.Ganguly . Alteration of the microenvironment in plasma membranes of rat enterocytes after Escherichia coli heat stable enterotoxin treatment : effect on protein kinase C. Biochem. Mol. Biol. Int. 35,567-574, 1995.

                                   No. of times cited :     5

46. G.Adhikary, S.Chandra, R.Sikdar and P.C.Sen. The phase behaviour of L-a- phosphatidyl choline in presence of chlorpromazine under different experimental  conditions. Colloids and Surfaces, 4, 335-339, 1995.

                                     No of times cited : 3

47. D.Ghosal, G.Adhikary, P.C.Sen and A.K.Barua. Na ,K -ATPase activity of different regions of rat brain in response to immunization and bone marrow cytokine treatment. Neuro Report 7, 865 - 868, 1996

                             No. of times cited : 2

48. P. C.Sen, J.Dutta and A.Ghosh. Lipid composition of Parshey roe (  Mugil  parsia  ). Ind.J.Chem.Soc. 74, 470 - 473, 1997.

No. of times cited : 2

49 D.Bhattacharyya and P.C.Sen. Purification and functional characterization of low molecular mass Na,K-ATPase inhibitor protein from rat brain cytosol. Eur.J.Biochem. 244,829 - 834, 1997

                              No. of times cited : 14

50. D.Bhattacharyya and P.C.Sen. Purification and functional characterization of a low molecular weight Ca,Mg- and Ca-ATPase modulator protein from rat brain cytosol. Biochem.J. 330, 95-101, 1998.

                             No. of  times cited : 20

52. Rinku Ghosh. P.C.Sen and S.Biswas. Mimosa pudica Apyrase requires polysaccharide and Ca for the activtiy. Mol.Cell.Biochem.  187, 47 - 55, 1998.  

                             No. of times of cited : 6            

53. D.Bhattacharyya and P.C.Sen. Interaction of chlorpromazine with low-molecular-mass ion transporting ATPase regulator proteins from rat brain cytosol. Ind.J.Biochem.Biophys. 36, 82-87, 1999.

                             No. of times of cited : 1             

54. D.Bhattacharyyya and P.C.Sen. The effect of binding of chlorpromazine and chloroquineto ion transporting ATPases.  Mol.Cell.Biochem. 198, 179-185, 1999

                             No. of times of cited : 19            

55. Roy, A.K.Mandal and P.C.Sen. A 75 kilodalton competitive inhibitorof Na,K-ATPase from rat brain cytosol binds to a site different from ouabain binding site. Eur.J.Biochem. 261, 84 - 88, 1999

                             No. of times of cited : 4

56. R.Sikdar, A.Mandal, K.Ray and P.C.Sen. Phosphorylation and dephosphorylation of         

Mg  -independent Ca  -ATPase from goat spermatozoa. J. Biosc. 24,  317 -  321,  1999.

                             No. of times of cited : 13

57. K.Roy, A.K.Mandal, R.Sikdar, S.Majumder, Y.Ono and P.C.Sen. Unsaturated fatty acid activated protein kinase ( PKx ) isolated from goat testis cytosol. Biochim. Biophys. Acta  1434, 161 – 169, 1999.

                              No. of times of cited : 5            

58. T.Das, G.Sa, V.Subhalakshmi, S.Subramaniam, P.C.Sen, S.Biswas and P.K.Ray. Protein A activated rat splenic lymphocyte proliferation involves tyrosine kinase- phospholipase C-protein kinase C pathway.  Immunopharmacol. Immunotoxicol. 22,    75-90, 2000.

                             No. of times of cited : 2

59. U.Ganguly, A.Ghosh Chaudhury, A.Basu and P.C.Sen. STa  induced translocation of protein kinase C from cytosol to membrane in rat enterocytes. FEMS Microbiology Letters 204, 65- 69,  2001 

                             No. of times of cited : 18

60. A.K.Mandal, K.Roy, P.C.Sil, S.P.Yadav  and P.C.Sen. Purification, characterization partial amino acid sequencing of a 70 kDa inhibitor protein of Na,K-ATPase from goat testis cytosol. Mol.. Cell. Biochem 223, 7 - 14, 2001

                             No. of times of cited : 4

61. P.C.Sen. Ion transporting enzymes and their regulation by endogenous modulators-   

     Proc. Natl Acad. Sci. ( Review ) 71 ( B ) , part  II,  83 – 102, 2001 


62. M.De, A.K.De, P.C.Sen and  A.B.Banerjee. Antimicrobial properties of Star anise

     ( illicium verum Hook f  ) . Phytotheraphy Research,  16, 94- 95,  2002

                             Citation  : 105

63. D. Bhattacharyya and  P.C.Sen. Ion transporting enzymes : An overview.

J.Assam Sc. Soc. ( Review ) 42, 53 – 64, 2002

64. H. Post, R.Wiche,  P.C. Sen , G. Hoffbauer, M.Albrecht,  J. Seitz, G. Aumüller, and B.Wilhelm. Identification of a plasma membrane Ca2+-ATPase in epithelial cells and aposomes of the rat coagulating gland. The Prostate, 52: 159-166,  2002       

                             No. of times of cited :  17      

65. A.Mukherjee, P.C.Sen and A.C.Ghose. Immunosuppression in hamsters with progressive visceral leishmaniasis is associated with an impairment of protein kinase C activity in their lymphocytes that can be partially reversed by okadaic acid or anti – transforming growt factor β antibody.  Infection & Immuninity. 71, 2439 – 2446, 2003 

                                  No. of times of cited : 22

66. S. Sánchez-Luengo, G. Aumüller, P. C. Sen, K. Röhm, and B. Wilhelm.  Interaction of PDC-109, the major secretory protein from bull seminal vesicles, with bovine sperm membrane ATPase. J.Androl. 25: 234-244, 2004

                                  No. of times of cited : 38

67.  D. Bhattacharyya, S. Ghosh, M. Chatterjee, A. Basu and P. C. Sen.  Mechanism of regulation of phosphorylation - dephosphorylation of  Ca2+, Mg2+- and Ca2+-ATPases by  modulator proteins isolated from rat brain cytosol. Ind.J. Biochem. Biophys. 41: 162-166, 2004

                                             No. of times of cited : 3    

68. B.Samanta, G.Mezo, K.P.Das,  A.C.Ghose,  F.Hudecz and P.C.Sen. Efficacy of the phosphorylation of synthetic peptides by purified catalytic subunit of PKA ( PKAcat)  depends on the amino acid sequence of the peptides.  J.Pep.Res. 65: 445-449, 2005.

                                                No. of times of cited : 5

69. P.Mukherjee, P.C.Sen and A.C. Ghose. Lymph node cells BALB/c mice with chronic visceral Leishmaniasis exhibit cellular anergy and apoptosis: Involvement of  Ser/Thr phosphatase. Apoptosis, 11:  2013-2029, 2006.

                                      No. of times of cited :  19

70. S. Ghoshal, T. Sengupta and P. C. Sen  Regulation of Mg+2 -  independent  Ca+2 - ATPase by a low molecular mass protein purified from bovine brain. Biofactors, 26 :  259-271,  2006

No. of times of cited : 2

71. J.K. Jha, M.K. Maiti, A.Bhattacharyya, A.Basu, P.C.Sen and S.K. Sen. Cloning and functional expression of a seed-specific fatty acyl carrier protein thioesterase from Diploknema (Madhuca) butyraceau in EscheRichia coli. Plant Physiol. Biochem. 44 :645-655, 2006

                                     No. of times of cited : 32        

72. T. Sengupta, S. Ghoshal and P.C. Sen.  Stimulation of Mg2+-independent form of Ca2+-ATPase by a low molecular mass protein purified from goat testes cytosol . Comp. Biochem. Physiol. Part. B.           146, 131-138, 2006

                                    No. of times of cited : 7

73. D. Bhattacharyya, A. Basu and P.C.Sen. Purification of protein from a crude mixture through SDS-PAGE transfer method.  Ind.J.Biochem.Biophys. 44, 122-125, 2007 

No. of times of cited : 3

74. M. Kundu, P.C.Sen  and K. P. Das. Structure, Stability and Chaperone Function of  α-crystallin:  Role of the N-Terminal Region. Biopolymers 86: 177-192, 2007

No. of times of cited : 44

75. B. Samanta, S.K. Nagdas, K.P. Das and P.C. Sen Protein kinase catalytic subunit

( PKAcat) from bovine lens: Purification, characterization and phosphorylation of lens crystallins. Mol. Cell. Biochem. 304, 155-165, 2007 

                                     No. of times of cited :  4

76.  T.  Sengupta,  SS. Ghosha, S.  Dunggung, G.C. Majumder and P.C.Sen .  Structural and functional characterization and physiological significance of a stimulation protein of  Mg2+-independent Ca2+-ATPase isolated rom goat spermatozoa. Mol. Cell. Biochem. 311, 93-103, 2008.

No. of times of cited : 4

77.  S. Ghoshal, T. Sengupta, G. C. Majumder and P. C. Sen Characterization of a low molecular mass stimulator protein of Mg2+-independent Ca2+-ATPase : effect on phosphorylation-dephosphorylation, calcium transport and sperm cell motility.  Biosc. Report . 28, 61-71, 2008.

No. of times of cited : 3

78.  T.K.Ray, P. Das, P.C.Sen and J. Nandi. Current Outlooks on the Gastric Membranes and Beyond.

  Trends in Cell and Molecular Biology ( Review). 3, 69-78, 2008

79. M.Chatterjee, P.Das, A.Mazumder, A.K.Nagdas and P.C.Sen.  Localization  and expression of  a 70 kDa protein in goat spermatozoa having Na,,K-ATPase and  aryl sulphatase –A activities. Mol. Cell. Biochem. 321, 85-94, 2009 

                                      Citation : 6

80. T. K. Dhara, M. Chatterjee, R. Bera and P. C. Sen. Characterization of arylsulphatase A in a 70 kDa protein isolated from goat spermatozoa having Na+, K+-ATPase inhibitory activity. Ind.J.Biochem. Biophys.  46, 230-236, 2009

                                      Citation : 2

81. M. Chatterjee, P. Nandi, S.  Ghosh and P. C. Sen. Regulation of tyrosine kinase activity during capacitation in goat sperm. Mol.Cell.Biochem. (Special Issue on Molecular Medicine and Cell Signaling)) 336, 39-48, 2010

                                      Citation : 10

82.  R. Bera, T. K. Dhara, R. Bhadra, G. C. Majumder and P. C SenEicosapentaenoic and docosahexaenoic acids enriched polyunsaturated fatty acids from the coastal marine fish of Bay of Bengal and their therapeutic value. Ind.J.Expt.Biol. 48, 1194-1203, 2010

                                              Citation : 1

83. C. Mukherjee, S. Ghosh, P. Nandi, P. C. Sen and A. K. Misra, Efficient synthesis of (6,6¢)-sulfonyl pseudodisaccharides and their effect on Ca2+-ATPase. Eur. J. Med. Chem. 45,6012-6019, 2010

                      Citation : 2

84. P.  C. Sen. Endogenous modulators in the regulation of ion transporting enzymes : A historical account, recent developments and future perspectives. Adv. Biol. Chem. 1, 75-92, 2011

85. P.C. Sen. Endogenous modulators in the regulation of ion transporting enzymes. Ind. J. Physiol. 65 (3), 122-128, 2011

86. N. Islam, S. Chanda, P.C. Sen and C. Mitra. Stress mediated alteration in membrane fluidity regulates Ca-ATPase activity in plasma membrane of duodenal entercytes of Oophorectomized rats. Al Ameen J. Med. Sc. 4, 28-37, 2011.

87. K. Jana and P. C. Sen.  Environmental Toxicants Induced Male Reproductive Disorders: Identification and Mechanism of Action. In ‘Toxicity and Drug Testing”. in Toxicity and Drug Testing, Edited by William Acree, Intech Publication, Croatia, pp. 473-518, 2012.

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  • The National Academy of Sciences ( F.N.A.Sc. ), India , 1998
  • West Bengal Academy of Science and Technology (F.A.Sc.T.), 2009
  • Prof. P.B. Sen Oration Award from the Physiological Society of India, 2010
  • Prof. P.A.Kurup Endowment Award from the Society of Biological Chemists ( India ), 2000
  • Prof. R.C.Shah Memorial Award from Indian Science Congress Association, 1997-98


Enzymology and Cell Biology Course to Ph.D.  students at Bose Institute; Cell Signaling course to Ph.D. students; Cell Biology to integrated M.Sc. Ph.D. students; Basic Biochemistry Course to M.Sc. Ph.D. students; Cell Biology and Nano-Medicine in Integrated M.Sc.Ph.D. Programme in Life Sciences (Bose Institute).   


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