Previous appointments:

* Institute for Genomics and Systems Biology, The University of Chicago
* Center for Computational Science and Engineering, University of California, Davis

Research interests:

For more details, please visit our group website.

Recently published and ongoing research includes but is not limited to the following areas:

Physical sciences:
* Networks and information theory
* Quantum entanglement on networks
* Phase transitions and critical phenomena
* Networks and game theory
* New measures in networks and their implications
* Innovative applications of networks, e.g. in Information retrieval, image processing,
   and non-invasive diagnostics, mutagenesis, phage resistance etc

Life sciences:
        * Communication, competition and co-operation in microbial systems
            +  Phage-bacteria interactions and dynamics
            +  Antimicrobial resistance
       
* Structure, function and dynamics of biological macromolecules

Contact:

Address: Physical Sciences
Unified Academic Campus
Bose Institute
EN-80, Sector V
Bidhan Nagar
Kolkata - 700 091, India
E-Mail: soumen[at]jcbose.ac.in
Phone: +91-33-25693232

Research:

For more details, please visit our group website.

Our interdisciplinary lab is a part of the Department of physical sciences. We have been associated with institutional research programmes themed around: (i) complex systems, (ii) physical and environmental sciences, and, (iii) systems and synthetic biology

We study a wide variety of physical and biological systems by applying tools from statistical physics, network science, non-linear dynamics and game theory. We also design and conduct experiments in parallel with mathematical modelling towards achieving a better understanding of biological systems. Recently published and ongoing projects are listed here.

Recent work by students of our lab has been published in interdisciplinary, physics and life science journals like Bioinformatics (Oxford), Europhysics Letters (EPL)Physical Review E (APS), Applied and Environmental Microbiology (ASM), Scientific Reports (Nature)  and  Frontiers in Physics (Frontiers). Our invited contributions have appeared in publications like Methods in Molecular Biology and Advances in Applied Microbiology

Publications:

Patents awarded as principal inventor:
A system and method for analyzing videos of application or function for feature identification of the videos and related application or function.
                [Patent No. 472279 (2023)]
Soumen Roy et al.                                                                

Copyrights registered as principal author:
Software for analyzing videos of application or function for feature identification of the videos and related application or function                [Registration no: SW-10052 (2018)]
Soumen Roy et al.                                                  

List of publications and preprints:
  
ORCID iD iconhttps://orcid.org/0000-0002-0417-5751
* Corresponding / Co-corresponding  author

Foreword: special issue on statistical physics and complex systems
Indian Journal of Physics (Springer), 98, 3753-3755 (2024)
Deepak Dhar and Soumen Roy

An ab initio information-theoretic approach to proteins and protein-ligand interactions (2024)
bioRxiv 2024.03.06.583646

Deep Nath, Rajdeep Kaur Grewal, Devrani Mitra and Soumen Roy*

Assessing combinatorial diversity of Aureochrome bZIPs through genome-wide screening
Cells Tissues Organs [Karger], 213, 133-146 (2024) [Invited]    bioRxiv 2022.06.05.494858
Madhurima Khamaru, Deep NathDevrani Mitra* and Soumen Roy*

Network approach to mutagenesis sheds insight on phage resistance in mycobacteria

Bioinformatics [Oxford], 37, 213-220 (2021)        PDF 
Saptarshi SinhaSourabh Samaddar, Sujoy Das Gupta
and Soumen Roy
* 
Summary     Popular coverage in: 
Research Matters        Daily Hunt 

Scale-free networks may not necessarily witness cooperation

Euro Physics Letters [EPL], 134, 60002 (2021)        arXiv:2101.01167   
Deep Nath
,
Saptarshi Sinha and Soumen Roy*

Topology dependent payoffs can lead to escape from prisoner's dilemma
European Physical Journal B, 94, 80 (2021)         arXiv:2006.14593
Saptarshi Sinha
,
Deep Nath and Soumen Roy*


Mass testing and proactiveness affect epidemic spreading
[Invited]
Special issue on "Emerging Trends in Modeling and Analysis of Complex Systems"
Journal of the Indian Institute of Science, 101, 371-380 (2021)
      
arXiv:2008.10387  

Saptarshi Sinha, Deep Nath and Soumen Roy*

Residue interaction dynamics in Vaucheria aureochrome1 light-oxygen-voltage: Bridging theory and experiments
Proteins: Structure, Function, and Bioinformatics [Wiley], 88, 1660-1674 (2020)
Anwesha Deb,
Rajdeep Kaur Grewal, Soumen Roy* and Devrani Mitra*

Modeling phage-bacteria dynamics
Methods in Molecular Biology, 2131, 309-327 (2020) [Springer]
Saptarshi Sinha, Rajdeep Kaur Grewal and Soumen Roy*


A pedestrian review of games on structured populations [Invited review]     PDF

International Journal of Advances in Engineering Sciences and Applied Mathematics [Springer], 11, 138-152 (2019)  
Saptarshi Sinha, Susanta Ghosh and Soumen Roy*

Role of a 19S proteasome subunit - PSMD10 / Gankyrin in neurogenesis of human neuronal progenitor cells

International Journal of Stem Cells, 12, 463-473 (2019)
Indrajit Sahu, Padma Nanaware, Minal Mane, 
Soumen Roy*, Prasanna Venkatraman*

Topologically inspired walks on randomly connected landscapes with correlated fitness

Frontiers in Physics [Frontiers] 6: 138 (2018)
    PDF 
Rajdeep Kaur Grewal,
Saptarshi Sinha and Soumen Roy*

Modeling bacteria-phage interactions and implications for phage therapy
Advances in Applied Microbiology [Academic Press], 103, 103-141 (2018)    

Saptarshi Sinha
Rajdeep Kaur Grewal and Soumen Roy
*


Dynamics of Mycobacteriophage-Mycobacterial host interaction - evidence for secondary mechanisms for host lethality

Applied and Environmental Microbiology [ASM] 82 124-133 (2016)     PDF    Supplementary Information
Sourabh Samaddar, RK Grewal, S Sinha, S Ghosh, Soumen Roy* and Sujoy Das Gupta*
Selected as article of significant interest by Editors for AEM Spotlight

Using complex networks towards information retrieval and diagnostics in multidimensional imaging
Scientific Reports [Nature] 5: 17271 (2015)     arxiv:1506.02602     PDF    

Soumya Jyoti Banerjee, Mohammad Azharuddin, Debanjan Sen, Smruti  Savale, Himadri Datta, Anjan Dasgupta and Soumen Roy*

Slow poisoning and destruction of networks: Edge proximity and its implications for biological and infrastructure networks
Physical Review E [APS] 91 022807 (2015)     arxiv:1409.8268    PDF
Soumya Jyoti Banerjee, Saptarshi Sinha and Soumen Roy*

Mapping networks of light-dark transition in LOV photoreceptors
Bioinformatics [Oxford] 31 3608-3616 (2015)    Supplementary Information
Rajdeep Kaur Grewal, Devrani Mitra and Soumen Roy*

Modeling proteins as residue interaction networks [Invited review]
Protein & peptide letters 22 923-933 (2015) 
Rajdeep Kaur Grewal and Soumen Roy*

Perspectives in systems biology
Editorial for special issue
Systems and Synthetic Biology [Springer] (2014) 8: 1-2    PDF
Soumen Roy*

Efficient scheduling using complex networks
arxiv:1206.2866
Osamu Yamaguchi, Soumen Roy* and Raissa M. D'Souza

Systems biology beyond degree, hubs and scale-free networks: the case for multiple metrics in complex networks

Systems and Synthetic Biology [Springer] (2012)  6: 31-34  arxiv:1205.2318     PDF
Soumen Roy*

Analysis of early host responses for asymptomatic disease detection and management of specialty crops
Critical Reviews in Immunology  30 277-289 (2010)


Resilience and rewiring of the passenger airline networks in the United States
Physical Review E  82  056101 (2010)  arxiv:0901.0774     PDF
Daniel R. Wuellner Soumen Roy* and Raissa M. D'Souza
Cited in:
(A) "Networks", Mark Newman, Oxford University Press, UK (2018)
(B)  AS 63 [Ref. 16], First Report of Session 2013-14 (Vol 1), House of Commons Transport Committee on Aviation Strategy, Parliament of UK.

Strong associations between microbe phenotypes and their network architecture
Physical Review E  (Rapid)  80  040902(R) (2009)  arxiv:0901.0775      PDF
Soumen Roy* and Vladimir Filkov

Modeling and verifying a broad array of network properties
Europhysics Letters  86 (2009) 28003   arxiv:0805.1489     PDF
Vladimir Filkov, Zachary M. Saul, Soumen Roy, Raissa M. D'Souza and Prem Devanbu
"Graphlet arrival model" has also been covered in the book: An Introduction to Computational Systems Biology: Systems-Level Modelling of Cellular Networks (Chapman & Hall/CRC Computational Biology Series)

Motion of a random walker in a quenched power law correlated velocity field
Physical Review E  73  026106 (2006)   cond-mat/0511008   PDF
Soumen Roy* and Dibyendu Das



Enhanced Thermodynamic efficiency in time asymmetric ratchets
J. Stat. Mech. (2005) P04012    cond-mat/0412303  PDF
Raishma Krishnan,  Soumen Roy* and A. M. Jayannavar

Invited book chapters:

"Allostery and networks" in "Advances in Biology"
Nova, New York, USA
(2023)
 Swati Sharma, Deep Nath
and Soumen Roy*

"Systems biology in plant cells and their organelles" in "Plant cells and their organelles"
John Wiley & Sons Ltd, UK (2017). Editors: Dashek and Miglani
Rajdeep Kaur Grewal, Saptarshi Sinha and Soumen Roy*
        [Book Review: "Perhaps the most important chapter in this book ...",
          Elizabeth Friar, Crop Science (2017) 57 3360 - 3361 ]

"Complex networks and systems biology" in "Systems and Synthetic Biology"
Springer Netherlands (2015).  Editors: Singh and Dhar

Ushasi Roy, Rajdeep Kaur Grewal and Soumen Roy*

"Networks, metrics and systems biology" in "A systems theoretic approach to systems and synthetic biology I: models and system characterizations"
Springer Netherlands (2014). Editors: Kulkarni, Stan and Raman

Soumen Roy*

Contributed book chapters:


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Recognition:

  • Regular Associate, International Centre for Theoretical Physics (UNESCO), Trieste, Italy, Since 2017
  • Academic Editor, PLOS ONE, Since 2018
  • Hon. Assoc Editor, Indian Journal of Physics (Springer), Since 2012
  • Editor, Special Issue on Statistical Physics and Complex Systems, IJP (Springer), 2024
  • Editor, Special Issue Systems and Synthetic Biology, 2014
  • Member, SSBRN Task Force, 12'th V-year Plan (2012-2017), Planning Commission, Govt. of India, 2012

Teaching:

Courses taught at Bose Institute:

Statistical analysis
   Ph.D.                                                                                                                 2024

Statistical mechanics
   Ph.D.                                                                                                                 2023
Computer programming with python

   Ph.D.  
                                                                                                               2023
Research ideology and research ethics
   Ph.D.                                                                                                                 2024
   Ph.D.                                                                                                                 2023
   Ph.D.                                                                                                                 2022
Numerical methods
   Ph.D.                                                                                                                 2022

Statistical physics - II

 
   Integrated Ph.D. in Physical Sciences                            2'nd semester, 2019-2020

Computational and systems Biology (609)

   Integrated Ph.D. in Life Sciences                                     3'rd semester, 2020-2021

Statistical Physics - I

   Integrated Ph.D. in Physical Sciences                              1'st semester, 2017-2018
  
Integrated Ph.D. in Physical Sciences                              1'st semester, 2016-2017
  
Integrated Ph.D. in Physical Sciences                              1'st semester, 2015-2016
Computation and numerical techniques - I
   Integrated Ph.D. in Physical Sciences                              1'st semester, 2014-2015
   Integrated Ph.D. in Physical Sciences                              1'st semester, 2013-2014
Dynamical systems (Tools of systems biology - II)
   Integrated Ph.D. in Life Sciences (Bose Institute)          2'nd semester, 2014-2015
   Integrated Ph.D. in Life Sciences (Bose Institute)          2'nd semester, 2013-2014
Networks (Computational and systems biology)
   Integrated Ph.D. in Life Sciences                                    3'rd semester, 2014-2015
   Integrated Ph.D. in Life Sciences                                    3'rd semester, 2013-2014
Concepts of approximations (Tools of systems biology - I)
   Integrated Ph.D. in Life Sciences                                     1'st semester, 2014-2015
   Integrated Ph.D. in Life Sciences                                     1'st semester, 2013-2014
   Integrated Ph.D. in Life Sciences
                                    1'st semester, 2012-2013
Special: systems biology, bioinformatics & biostatistics   4'th semester, 2013-14
   M.Sc.                                                                                     University of Calcutta
Computer applications                                                                                2011-12
    Ph.D. 
                                                                                                          2010-11
    Course Material and Assignments:                                              Please Click here


Students:

Image Name Designation Department Campus Contact number Email
profile image Arijit Roy Junior Research Fellow Physics Unified arijitroy@jcbose.ac.in
profile image Ramnarayan Bera Junior Research Fellow Physics Unified ramnarayan97@jcbose.ac.in
profile image Swati Sharma Junior Research Fellow Physics Unified swatisharma@jcbose.ac.in

Former:

Former Doctoral Fellows:

Saptarshi Sinha
Dr. Saptarshi Sinha
Current / next affiliation: Univ. of California, San Diego, USA

B. Sc.
(Microbiology Hons): St. Xavier's College, Kolkata
M. Sc. (Microbiology):University of Pune
Ph.D. (Microbiology): University of Calcutta
Ph.D. thesis title: Competition and cooperation in microbes

Rajdeep

Dr. Rajdeep Kaur Grewal 
Current / next affiliation: Ohio State University, USA

B. Sc. (Maths. Hons): Bethune College, Kolkata
M. Sc. (Applied Mathematics): University of Calcutta
Ph. D. (Applied Mathematics): University of Calcutta
Ph.D. thesis title: Studies on Biological Networks

Soumya

Dr. Soumya Jyoti Banerjee
Current / next affiliation
TCS Research and Innovation

B.Sc. (Maths. Hons): Ramakrishna Mission Vidyamandira, Belur
M. Sc. (Applied Mathematics): University of Calcutta
Ph. D. (Applied Mathematics): University of Calcutta
Ph.D. thesis title: Structural aspects of complex networks and their applications

Deep Nath
Deep Nath
Current / next affiliation: Ph.D. Thesis submitted

B. Sc.
(Physics): Krishnath College, Kalyani University 
M. Sc. (
Physics): Banaras Hindu University, Varanasi
Ph.D. Registration: University of Calcutta (Theoretical Physics)
Ph.D. thesis title: Information, games and graphs



Former Doctoral Fellows supervised as Associate Supervisor: 

Sumana Gop
Sumana Gop
Current / next affiliation: Officer, Indian Railways

B. Sc. (Physics): Visva-Bharati University, Santiniketan
M. Sc. (Physics): Indian Institute of Technology (IIT), Kharagpur
Ph.D. Registration: University of Calcutta (Theoretical Physics)
Ph.D. thesis title: Binding mechanism of anti-cancer agents with DNA bases and base pairs using density functional theory


Group News:



For more details, please visit
our group website.