Research:

Publications:

Saha S, Tewary A, Ghosh Majumdar S, Cabal M and Mukhopadhyay J. RFA1 inhibits rifampicin-resistant RNA polymerase by binding by a similar mechanism as rifampicin. Journal of Molecular Biology, (2026) https://doi.org/10.116/j.jmb.2026.169773 

Nilanjana Hazra N and Mukhopadhyay J. Differential Association of Primary and Alternative σ Factors with RNA Polymerase of M. Tuberculosis during Transcription Elongation, Nucleic Acids Research, (2026), 54, gkaf1459. 

Tewary A, Sengupta S, Mukherjee S, Hazra N, Ebright YW, Ebright RH, and Mukhopadhyay J. Bacillus subtilis σA and Escherichia coli σ70 lacking σ region 1.1 are not released during transcription initiation and elongation.  Proc Natl Acad Sci, USA (2025) doi:10.1073/pnas. 2503801122. 

Jaiswal R, Dutta S, Mukherjee S, Hazra N, Saha S, and Mukhopadhyay J. The genomic SELEX-based method identifies 350 SigA-specific promoters in Mycobacterium tuberculosis. FEBS Journal (2025) doi: 10.1111/febs.70251. 

Hazra N and Mukhopadhyay J, Recent Advances in Mycobacterial Transcription: Insights Beyond the General Pathway. Journal of Bacteriology (2025) doi: 10.1128/jb.00154-25 

Butler RE, Schuller M, Jaiswal R, Mukhopadhyay J, Barber J, Hingley-Wilson S, Wasson E, Alves AC, Ahel I, and Stewart GR. Control of replication and gene expression by ADP-ribosylation of DNA in Mycobacterium tuberculosis. EMBO J (2025) doi.org/10.1038/s44318-025-00451-y 

Tewary A, Prajapati RK, and Mukhopadhyay J. Mechanism of d Mediated Transcription Activation in Bacillus subtilis: Interaction with a CTD of RNA Polymerase Stabilizes d and Successively Facilitates the Open Complex Formation, Journal of Molecular Biology (2023) 435 168366 

Chakraborty AK, Saha S, Kousik K, Samanta T, Gautam S, Mukhopadhyay J. A saponin-polybromophenol antibiotic (CU1) from Cassia fistula Bark Against Multi-Drug Resistant Bacteria Targeting RNA polymerase. Current Research in Pharmacology and Drug Discovery (2022) 3: 100090. 

Sharma S, Kumar R, Jain A, Kumar M, Gauttam R, Banerjee R, Mukhopadhyay J, Tyagi JS. Functional insights into Mycobacterium tuberculosis DevR-dependent transcriptional machinery utilizing Escherichia coli. Biochem J. (2021) 478 (16):3079-3098. 

Mallik R, Prasad P, Kundu A, Sachdev S, Biswas R, Dutta A, Roy A, Mukhopadhyay J, Bag SK, Chaudhuri S. Identification of genome-wide targets and DNA recognition sequence of the Arabidopsis HMG-box protein AtHMGB15 during cold stress response. Biochim Biophys Acta Gene Regul Mech. (2020) 1863(12):194644. 

Dutta A, Rudra P, Banik SK, Mukhopadhyay J. Evidence of robustness in a two-component system using a synthetic circuit. (2020) J Bacteriol. 202 (4) e00672-19.  

Bhawsinghka N, Dutta A, Mukhopadhyay J, Das Gupta SK. A transcriptomic analysis of the mycobacteriophage D29 genome reveals the presence of novel stoperator-associated promoters in its right arm, (2018) Microbiology Sep;164(9):1168-1179. 

Mallick Gupta A, Mukherjee S, Dutta A, Mukhopadhyay J, Bhattacharyya D, Mandal S. Identification of a suitable promoter for the sigma factor of Mycobacterium tuberculosis. (2017) Mol Biosyst 13:2370-2378 

Prajapati RK, Sur R, Mukhopadhyay J.  A Novel function of factor from Bacillus subtilis as a transcriptional repressor (2016) J Biol Chem. 291(46): 24029-24035. 

Datta A, Yadav V, Ghosh A, Choi J, Bhattacharyya D,. Kar R K, Ilyas H, Dutta A, An E, Mukhopadhyay J, Lee D, Sanyal K, Ramamoorthy A, and Bhunia A. Mode of Action of a Designed Antimicrobial Peptide:High Potency Against Cryptococcus neoformans. (2016) Biophysical Journal 111: 1724–1737 

Roy A, Dutta A, Roy D, Ganguly P, Ghosh R, Kar RK, Bhunia A, Mukhopadhyay J, and Chaudhuri S. Deciphering the role of the AT-rich interaction domain and the HMG-box domain of ARID-HMG proteins of Arabidopsis thaliana. (2106) Plant Molecular Biology 92(3):389-390. 

Prajapati RK, Sengupta S, Rudra P, Mukhopadhyay J. Bacillus subtilis δ Factor Functions as a Transcriptional Regulator by Facilitating the Open Complex Formation. (2016) J Biol Chem. 291(3):1064-75. 

Promoter escape with bacterial two-component sigma factor suggests retention of sigma region two in the elongation complex. Sengupta S, Prajapati RK, and Mukhopadhyay J. (2015) J Biol Chem. 290(47):28575-83.  

Rudra P, Prajapati RK, Banerjee R, Sengupta S, and Mukhopadhyay J*. Novel mechanism of gene regulation: the protein Rv1222 of Mycobacterium tuberculosis inhibits transcription by anchoring the RNA polymerase onto DNA. (2015)  Nucleic Acid Research, 43: 5855-67.  

Saha A, Mukhopadhyay J, Datta AB, Parrack P. Revisiting the mechanism of activation of cyclic AMP receptor protein (CRP) by cAMP in Escherichia coli: Lessons from a subunit-crosslinked form of CRP. (2015)  FEBS Letters 589: 358–363. 

Sharma AK, Chatterjee A, Gupta S, Banerjee R, Mandal S, Mukhopadhyay J, Basu J, Kundu M. MtrA, an essential response regulator of the MtrAB two component system regulates the  transcription of resuscitation promoting factor B (RpfB) of Mycobacterium tuberculosis. (2015) Microbiology 161(6):1271-81. 

Banerjee R, Rudra ., Saha A, and Mukhopadhyay J. Recombinant Reporter Assay Using Transcriptional Machinery of Mycobacterium tuberculosis. (2015) Journal of Bacteriology 197, 646-653. 

Banerjee R, Rudra P, Prajapati, RK, Sengupta S., and Mukhopadhyay J. Optimization of recombinant Mycobacterium tuberculosis RNA polymerase expression and purification. (2014) Tuberculosis (Edinb) 94:397-404. 

Polyphosphate kinase 1, a central node in the stress response network of Mycobacterium tuberculosis, connects the two-component systems MprAB, SenX3-Reg X3 and the extra-cytoplasmic function sigma factor, Sigma E. Sanyal S, Banerjee, S K Banerjee, R, Mukhopadhyay J,  Kundu, M. (2013) Microbiology 159: 2074-86.  

Recognition:

Teaching:

Students:

Image	Name	Designation	Department	Campus	Contact number	Email
	Maitrayee Mandal	Junior Research Fellow	Chemical Sciences	Unified		info.maitrayee@gmail.com
	Nilanjana Hazra	Junior Research Fellow	Chemistry	Main		nilanjana.hazra@jcbose.ac.in
	Soumyadeep Mukherjee	Junior Research Fellow	Chemical Sciences	Unified		soumya.mcb1997@gmail.com
	Suravi Nandi	Junior Research Fellow	Chemistry	Unified		snb9496@gmail.com

Former:

Group News:

Indian scientists throw new light on bacterial transcription mechanism to combat TB | DD News https://ddnews.gov.in/en/indian-scientists-throw-new-light-on-bacterial-transcription-mechanism-to-combat-tb/