Kuladip Jana

Kuladip Jana
Principal Scientist

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Previous appointments:

Research Associate, Immunology and Vaccine Development Unit, National Institute of Cholera & Enteric Diseases (NICED), Kolkata.

Research Associate, Crystallography & Molecular Biology Division, Saha Institute of Nuclear Physics, Kolkata.

Postdoctoral Research Associate, Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.

Research interests:

(A) Molecular signaling involved in patho-physiological action of Environmental pollutants in Germ cell DNA damage and Sperm line Stem Cell apoptosis in connection to male infertility: possible protection by natural phytochemicals.

(B) Molecular Mechanisms of Germ/Sperm-line Stem Cell Regulation: Special emphasis on Diabetes and aging.

(C) Cancer chemoprevention with new sulforaphane derivatives: involvement of Wnt/β-catenin signaling.

(D) Microtubular dynamics interfering agent causes apoptosis through endoplasmic reticulum stress pathway and sensitizes the breast cancer cells through AP1 mediated TGFBI over- expression.

(E) Development of the anti-filarial drugs from natural sources: Molecular and cellular approach.

(F) Anti-cancer and Anti-metastatic drug development from natural product-derived small molecules

(G) Functionalized Metal-Organic Frameworks (MOFs), hydrogels, and cumbersome nanoparticles for targeted delivery of anticancer and anti-metastatic agents.

(H) Amino acid-based photosensitive cationic nano micelle for targeted miRNA delivery for Cancer Immunotherapy


Contact:

Address: Biological Sciences
Unified Academic Campus
Bose Institute
EN-80, Sector V
Bidhan Nagar
Kolkata - 700 091, India
E-Mail: kuladip[at]jcbose.ac.in
Phone: +91-33-25693264

Research:

 A novel sulforaphane derivative SP12 induces apoptosis and prevails paclitaxel resistance through over expression of TGFBI protein.

Extracellular matrix (ECM) proteins including ECM receptors and their counterpart binding proteins have been largely associated with tumor cell progression and metastasis. Transforming growth factor-b-induced (TGFBI or keratoepithelin or βIg-h3), one of the ECM protein which has been implicated in a number of cellular disease processes including angiogenesis, tumor progression and metastasis. TGFBI, a 68-kDa protein contains four conserved fasciclin-1 (FAS1) domains and a C-terminal RGD integrin-binding sequence. TGFBI mediates integrin binding to ECM proteins such as collagen, laminin and fibronectin. TGFBI binding to integrins has been related to the activation of cell proliferation, adhesion, migration and differentiation. This protein is down-regulated various human cancers including Ovarian cancer, lung cancer and breast cancer where it acts a tumor suppressor. Interestingly, we have identified a novel sulforaphane derivative SP12 which induces the over expression of TGFBI in paclitaxel resistant SKOV-3 (ovarian cancer), MCF-7/P (breast cancer) and A549/P (lung cancer) cell lines. As reports suggests that JNK signaling pathway activates during TGFBI over-expression. Treatment of SP-12 showed significant increase in the expression of TGFBI along with c-Jun in above cell lines. On the other hand Malt inspector analysis also revealed probable binding site for c-Jun transcription factor in TGFBI promoter region. So, our first objective is to validate the role of c-Jun transcription factor and JNK/SAPK pathway in SP-12 mediated over expression of TGFBI.Microtubule dynamic interfering agents such as paclitaxel (taxol), docetaxel (taxotere), vinblastine, vincristine and colchicines have been involved in activation of the c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) signaling pathway in a variety of human cells actually requires interactions with microtubules. Preliminary experiment with SP12, demonstrated higher expression level of an important ER stress biomarker CHOP/DDIT3/GADD153. Again, ER stress has been reported to be linked with activation of JNK/SAPK pathway. Thus, SP12 mediated activation of JNK/SAPK pathway may have a critical role in ER stress. So, our second objective is to deduce the role of SP12 mediated activation of JNK/SAPK in ER stress dependent apoptosis. A recent report suggests TGFBI over expression sensitizes ovarian cancers to paclitaxel via FAK- and Rho-dependent stabilization of microtubules by binding to integrin-αvβ3. So our third objective is to check the function of SP-12 mediated over expression of TGFBI in paclitaxel sensitivity in paclitaxel resistant cells using paclitaxel and SP-12 in combination.



A microtubular dynamics interfering trans-stilbene derivative compound G drives G2/M arrest, apoptosis and impedes cancer progression.

Resveratrol, a trans –stilbene polyphenolic compound and its synthetic analogs have been widely used bioactive molecules due to their remarkable chemopreventive potential. Here, we have identified a novel resveratrol analog, compound G ((Z)-3-(3, 4-dimethoxyphenyl)-2-(3, 4, 5-trimethoxyphenyl) acrylonitrile which inhibits proliferation of several cancer cell lines in vitro through microtubule depolymerization that induced G2M arrest and consequently leads to apoptotic cell death. Importantly, compound G shows limited cytotoxicity to normal cells as compared to cancer cells. Moreover, insight into the molecular and mechanistic detailed studies we reasoned that compound G induces increase in the expression of pro-apoptotic proteins and decrease in the expression anti-apoptotic proteins that decisively helps the activation of caspase 8, caspase 9, caspase 3, leading to PARP-1 and cell death via intrinsic and extrinsic pathways of apoptosis. More importantly, we also have established the crucial contribution of tumor suppressor protein p53 in compound G mediated apoptosis. Interestingly, the compound G also imparts its anti tumorigenic effect by inhibiting clonogenic property and anchorage independent growth potential of cancer cells. Finally, in vivo study with immune-competent syngeneic mice tumor model shows that administration of compound G is able to impede tumor progression without any side effects. So, our presently studied novel trans-stilbene derivative compound G has tremendous anti-tumorigenic potential and can be added to the current regimes of chemotherapy.



Insulin defective stage of type 2 Diabetes (IDS-T2DM) induced testicular Germ cell death/apoptosis in association with the up-regulation of Nrf2 expression: Ameliorative potential of sulforaphane (SFN) and resveratrol (RES).

Diabetes-induced testicular cell death is due predominantly to oxidative stress. Nuclear factor (erythroid- derived 2)-like 2 (Nrf2) is an important transcription factor in controlling the anti-oxidative system and is inducible by sulforaphane (SFN) and resveratrol (RES). To test whether SFN/RES prevents diabetes-induced testicular germ cell death/apoptosis, an insulin-defective stage of type 2 diabetes (IDS-T2DM) was induced in mice. This was accomplished by feeding them a high-fat diet (HFD) for 3 months to induce insulin resistance and then giving one intraperitoneal injection of streptozotocin to induce hyperglycemia while age-matched control mice were fed a normal diet (ND). IDS-T2DM and ND-fed control mice were then further subdivided into those with or without 3-months SFN/RES treatment. IDS-T2DM induced significant increases in testicular germ cell death/apoptosis presumably through receptor and mitochondrial pathways, shown by increased ratio of Bax/Bcl2 expression and cleavage of caspase-3 and caspase-8 without significant change of endoplasmic reticulum stress (GRP78/CHOP). Diabetes also significantly increased testicular oxidative damage and inflammation (TNFα and NFκB). All of these diabetic effects were significantly prevented by SFN/RES treatment with up-regulated Nrf2 expression. These results suggest that IDS-T2DM induces testicular germ cell death/apoptosis presumably through caspase-8 activation and mitochondria-mediated cell death pathways and also by significantly down-regulating testicular Nrf2 expression and function. SFN/RES up-regulates testicular Nrf2 expression and its target antioxidant expression, which was associated with significant protection of the testis from IDS-T2DM-induced germ cell death.

Diabetes-and Ageing associated decrease in adhesion of Testicular Germ line/Spermatogonial Stem cells to the Niche resulted DNA damage and apoptosis along with disrupted GDNF signaling: Protective role of Sulforaphane with the up-regulation of Nrf2.


Germ-line stem cells (GSCs), which can self-renew and generate differentiated progeny, are unique stem cells in that they are solely dedicated to reproduction and transmit genetic information from generation to generation. Through the use of genetic techniques in Drosophila, Caenorhabditis elegans, and mouse, exciting progress has been made in understanding molecular mechanisms underlying interactions between stem cells and niches. The knowledge gained from studying GSCs has provided an intellectual framework for defining niches and molecular regulatory mechanisms for other adult stem cells. In most stem cell systems, one major GSC signaling pathway has been identified that relies on a signal provided by the niche and received by the germ cells. Mosaic analysis, tissue-specific gene expression assays, and transplantation experiments have determined the tissue dependence of the respective factors. Finally, knockout and overexpression or ectopic expression experiments have been used to examine whether a particular signaling pathway plays an instructive role. The major signaling pathways identified include BMP, JAK/STAT, Notch, and GDNF. More detailed analysis of these and additional signaling pathways has provided insight into intricate regulatory networks. As an increasing amount of information emerges, it is becoming clearer how a balance between self-renewal and differentiation is achieved at the molecular level. In the adult, niche signals, GSC-to-niche adhesion, GSC proliferation, and apoptosis are affected by both external and internal conditions. Diabetes and aging are associated with delay or complete failure in GSC self-renewal in both males and females. The effects of diabetes and aging can be overcome by the expression of niche factors, such as the ligands of the BMP and JAK/STAT pathways, the adhesion molecule E-cadherin, or the cell cycle regulator STRING, a Cdc25 homolog. Interestingly, with diabetes and aging the number of GSCs decreases less than expected, likely due to replacement of lost stem cells by symmetrical division, leading to clonal expansion of a subset of GSCs. If a similar process occurs in mammals, such a clonal expansion could contribute to the accumulation of genomic defects in the progeny of diabetes/aged parents.





Publications:

1.

1.      Halder S, Das T,  Kushwaha R, Misra AK, Jana K*, Das D*. Targeted and Precise Drug Delivery Using a GSH-Responsive Ultra-Short Peptide-Based Injectable Hydrogel for Breast Cancer Cure. Materials Horizons, 2025, 12: 987- 1001 (Impact Factor 12.2)

2.      Dutta A, Chakraborty S, Bhattacharya A, Basak U, Pati S, Mukherjee S, Guha D, Banerjee S, Ray Chaudhuri N, Sarkar DK, Jana K, Sa G, Ghosh Dastidar S, Das T. Cross-regulation between FOXC1 and OCT4/SOX2 ensures acquisition of chemoresistance in breast cancer stem cells: Amendment by hsa-miR-5688. Molecular Therapy Oncology 2025 (In Press) (Impact Factor 5.3)

3.      Manik SK, Halder S, Bhattachrya A, Debnath U, Ali Sk,  Jana S, Shit M, Haldar P, Hazra D, Maity K, Ghorui S, Samanta S,  Misra  AK, Jana K*, Hazra N*. Design, Synthesis, and in Vitro and in Vivo Biological Evaluation of 2-Amino-Naphtho [2,3-B] Thiophene 4,9-Dione Derivatives as Potent Anti-Cancer Agents. European Journal of Medicinal Chemistry 2025 10.2139/ssrn.5167802 (In-Press) (Impact Factor: 7.088).

4.      Das A, Ray A, Ray Chaudhuri N, Mukherjee S, Dastidar SG, Ghosh A, Ganguly S, Jana K, Sarkar S. Binary protein interactome mapping of the Giardia lamblia proteasome lid reveals extra proteasomal functions of GlRpn11. The FEBS Journal, 2025, https://doi.org/10.1111/febs.70027 (Impact Factor 5.4)

5.      Banik D,  Banerjee S, Halder S, Ganguly R, Karak A, Ghosh P, Jana K, Mahapatra, A. A Dual-Responsive Ratiometric Fluorescent Probe for the Detection of Hypochlorite and Hydrazine in Environmental Samples, Live Cells, and Plant Tissues. Analytical Methods 2025 10.1039/D5AY00153F. (Impact Factor: 3.532).

6.      Basak U, Chakraborty S, Mukherjee S, Pati S, Khan P, Ghosh S, Adhikary A, Jana K, Sa G, Das T. Breast cancer stem cells convert anti-tumor CD4+ T cells to pro-tumor T regulatory cells: Potential role of exosomal FOXP3. Cellular Immunology 2025, 409-410:104931(Impact Factor 3.7)

7.      Rahaman SKB, Halder S, Roy KP; Halder PK, Debnath U, Jana K*. Discovery of new 4-aminoquinoline-thiazolidinone hybrid analogues as anti-proliferative agents inhibiting TLR4-LPS-mediated migration in triple-negative breast cancer cells. Chemical Biology & Drug Design. 2025, In Press (Impact Factor 3.2)

8.      Chowdhury K, Shit M, Halder S, Samanta A, Dutta B, Ali Md. A, Jana K, Sinha C. Structure of Protonated Baclofen [AuCl4], Theoretical Elucidation and Biological Studies. Applied Organometallic Chemistry 2025, 39: 10.1002/aoc.70142 (Impact Factor: 4.072)

9.      Sen A, Dewaker V, Debnath U, Rath J, Jana K*, Joardar N*, Sinha Babu S*. In silico exploration and in vitro validation of the filarial thioredoxin reductase inhibitory activity of Scytonemin and its derivatives. Journal of Biomolecular Structure and Dynamics. 2025, 43: 890-902 (Impact Factor: 5.235).

10.  Dhar, S., Sarkar, T., Bose, S., Pati, S., Chakraborty, D., Roy, D., Panda, A.K., Guin, A., Mukherjee, S., Jana, K. and Sarkar, DK., Sa, G. FOXP3 Transcriptionally Activates Fatty Acid Scavenger Receptor CD36 in Tumour‐Induced Treg Cells. Immunology, 2025; 174:296–309 (Impact Factor 4.9)  

11.  Dutta A, Halder S, Bhowmik I, Debnath U, Dhara D, Misra AK, Jana K*. A novel sulforaphane analog, disrupts PI3K/Akt pathway and inhibits cancer cell progression via ROS mediated caspase independent apoptosis. ACS Pharmacology & Translational Science 2024, 7: 195-211 (Impact Factor: 6.0).

12.  Rana A, Halder S, Chakraborty R, Debnath U, Jana K*, Misra AK. Novel aryl (dithioglycosyl) methane derivatives as anti-proliferative agents. Bioorganic Chemistry 2024, 154: 108030  (Impact Factor 4.5)

13.  Giri D, Dey SK, Manna S, Das Chaudhuri A, Mahata R,  Pradhan A, Roy T, Jana K, Das S, Roy S, Maiti Choudhury S. Nanoconjugate Carrying pH-Responsive Transferrin Receptor-Targeted Hesperetin Triggers Triple-Negative Breast Cancer Cell Death through Oxidative Attack and Assemblage of Pro-Apoptotic Proteins. ACS Applied Biomaterials 2024, 7: 7556–7573. (Impact Factor 4.8)

14.  De S,  Ghosh S, Roy S, Jana K, Mandal SC, Pal M. Polyphenol-rich fraction of Bergenia ligulata (Wall.) Engl. sensitizes colon and breast cancer metastasis in vivo: Evidence of cell-type specific mechanism. bioRxiv, 2024.10. 06.616842.

15.  Ghosh T, Datta SP,  Mandal P,  Patra N,  Jana K,  Ganguly S, Sarkar S. Two paralogues of N-ethylmaleimide sensitive factor: An exception to the minimal vesicular trafficking machinery of Giardia. bioRxiv, 2024.2024.08.20.608744

16.  Mal, S., Majumder, D., Birari, P., Sharma, A.K., Gupta, U., Jana, K., Kundu, M. and Basu, J. The miR-26a/SIRT6/HIF-1α axis regulates glycolysis and inflammatory responses in host macrophages during Mycobacterium tuberculosis infection. FEBS Letters 2024, 598: 2592–2614 (Impact Factor: 3.8).

17.  Pariary R, Shome G, Kalita S, Kalita S, Roy A, Harikishore A, Jana K, Senapati D, Mandal B, Mandal AK, Bhunia A. Peptide-Based Strategies: Combating Alzheimer’s Amyloid β Aggregation through Ergonomic Design and Fibril Disruption. Biochemistry 2024, 63:2397-2413 (Impact Factor: 3.0).

18.  Maiti A, Manna SK, Halder S, Ganguly R, Karak A, Ghosh P, Jana K, Mahapatra AK. Near-Infrared Fluorescent Turn-On Probe for Selective Detection of Hypochlorite in Aqueous Medium and Live Cell Imaging. ACS Chemical Research in Toxicology, 2024, 37:1682-1690 (Impact Factor: 3.8).

19.  Pariary R, Shome G, Dutta T, Roy A, Misra AK, Jana K, Rastogi S, Senapati D, Mandal AK, Bhunia A. Enhancing amyloid beta inhibition and disintegration by natural compounds: A study utilizing spectroscopy, microscopy and cell biology. Biophysical Chemistry 2024, 313: 107291 (Impact Factor: 3.3).

20.  Roy S, Roy S, Halder S, Jana K, Ukil A. Leishmania exploits host cAMP/EPAC/calcineurin signaling to induce an IL-33-mediated anti-inflammatory environment for the establishment of infection. The Journal of Biological Chemistry 2024, 300: 107366 (Impact Factor: 5.486).

21.  Patra R, Halder S, Saha R, Jana K*, Sarkar K* Highly Efficient Photoswitchable Smart Polymeric Nanovehicle for Gene and Anticancer Drug Delivery in Triple-Negative Breast Cancer. ACS Biomaterials Science & Engineering 2024, 10: 2299–2323 (Impact Factor: 5.8)

22.  Sengupta P, Dutta A, Suseelaa YV, Roychowdhury T, Banerjee N, Dutta A, Halder S, Jana K, Mukherjee G, Cattopadhyay S, Govindaraju T, Chatterjee S. G-quadruplex structural dynamics at MAPK12 promoter dictates transcriptional switch to determine stemness in breast cancer. Cellular and Molecular Life Sciences 2024, 81: 33 (Impact Factor: 9.261)

23.  Shit M, Halder S, Manna K, Karan A, Samanta A, Manik NB, Pal S, Jana K*, Sinha C. Mn (II) 3D coordination framework with mixed 5-aminoisophthalato and Pyridyl-isonicotinoyl Hydrazone Bridges: Structure, Electrical Conductivity, Anti-cancer Activity and Drug delivery. ACS Applied Polymer Materials 2024, 6: 2637-2648 (Impact Factor: 5.0)

24.  Banerjee S, Banik D, Halder S, Karak A, Ghosh P, Jana K, Mahapatra AK. A ratiometric small-molecule fluorescent probe for the selective detection of hypochlorite by an oxidative cyclization reaction: application to commercial disinfectants and live cells. Organic & Biomolecular Chemistry 2024, 22: 1662-1670. (Impact Factor: 3.2)

25.  Sengupta P, Roy A, Roy L,  Bose D, Halder S,  Jana K, Mukherjee G, Chatterjee S. Long non-coding intergenic RNA, LINC00273 induces cancer metastasis and stemness via miRNA sponging in triple negative breast cancer. International Journal of Biological Macromolecules. 2024, 274:132730 (Impact Factor: 7.7)

26.  Tapias BB, Halder S, Mendiola MA , Sinha C, Jana K*, Lopez-Torres E* New tin(IV) and organotin(IV) complexes with a hybrid thiosemicarbazone/hydrazone ligand: synthesis, crystal structure and antiproliferative activity. Bioinorganic Chemistry and Applications 2024, 2024: 1-16 (Impact Factor: 4.7)

27.  Birari P, Mal S, Majumder D, Sharma A, Kumar M, Das T, Jana K, Ghosh Z, Gupta U, Kundu M, Basu J. Nur77 influences immunometabolism to regulate the release of proinflammatory cytokines and the formation of lipid bodies during Mycobacterium tuberculosis infection of macrophages. Pathogens and Disease 2023, 81:ftad033 (Impact Factor: 3.3)

28.  Paul S, Debsharma K, Dey S, Halder S, Jana K, Sinha C. Naphthyl-azine–aggregation induced emission, reversible acidochromism, cyanide sensing and its application in intracellular imaging. Materials Advances 2023, 4: 3874-3891. (Impact Factor: 5.2)

29.  Maiti A, Banik D, Halder S, Manna SK, Karak A, Jana K, Mahapatra AK. Near-infrared fluorescent turn-on probe for hydrazine detection: environmental samples and live cell imaging. Organic & Biomolecular Chemistry 2023, 21: 6046-6056. (Impact Factor: 3.2)

30.  Karak A, Banerjee S, Halder S, Mandal M, Banik D, Maiti A, Jana K, Mahapatra AK. Visual and ratiometric fluorescent probe via an intramolecular charge transfer for detection of a nerve agent simulant in solutions and in the gas phase. New Journal of Chemistry 2023, 47: 16756-16763. (Impact Factor: 3.3)

31.  Banik D, Karak A, Halder S, Banerjee S, Mandal M, Maiti A, Jana K, Mahapatra AK. A turn-on fluorescent probe for selective detection of H 2 S in environmental samples and bio-imaging in human breast cancer cells. Organic & Biomolecular Chemistry 2023, 21: 8020-8030 (Impact Factor: 3.2  )

32.  Karim S, Halder S, Mukherjee S, Debnath U, Misra A, Jana K*, Das D*. Glutathione Depleting a Chemoselective Novel Pro-Oxidant Nano Metal-Organic Framework Induced G2/M Arrest and ROS Mediated Apoptotic Cell Death in Human Triple Negative Breast Cancer Cell Line. ACS Applied Materials & Interfaces 2023, 15: 26442-26456.  (Impact Factor: 10.383)

33.  Shit M, Halder S, Dey A, DuttaB, Chanthapally A, Jana K*, Sinha C* Pyridyl-isonicotinoyl Hydrazone Bridged Zn (II) coordination framework with Thiophenedicarboxylato link: Structure, Biological activity and Electrical Conductivity. Inorganic Chemistry 2023, 62: 19937-19947 (Impact Factor: 5.436)

34.  Das P, Mitra D, Jana K, Ghosh D. In Vitro Study on Spermicidal Action of Hydro-methanol Extract of Tinospora cordifolia (Willd.) Stem in Rat and Human Sperm: a Comparative Analysis. Reproductive Science 2023, 30: 3480–3494 (Impact Factor: 3.0).

35.  Saha R, Haldar S, Pradhan SS, Jana K, Sarkar K. Superior gene transfection efficiency in triple negative breast cancer by RAFT-mediated amino acid-based cationic diblock copolymers. Journal of Materials Chemistry B 2023, 11: 3617-34. (Impact Factor: 7.571)

36.  Pariary R, Dolui S, Shome G, Mohid SA, Saha A, Ratha BN, Harikishore A, Jana K, Mandal AK, Bhunia A, Maiti NC. Coomassie brilliant blue G-250 acts as a potential chemical chaperone to stabilize therapeutic insulin. Chemical Communications (Camb) 2023, 59: 8095-8098 (Impact Factor: 6.065)

37.  Paul S, Dutta B, Halder S, Shit M, Ray P, Ray PP, Jana K, Sinha C. Double advantages of 2D Coordination Polymer of Coumarinyl-Pyridyl Schiff base decorated Zn(II) : the fabrication of Schottky device and Anti-carcinogenic activity. Applied Organometallic Chemistry 2023, 37: e7160 (Impact Factor: 4.072)

38.  Lepcha TT, Kumar M, Sharma AK, Mal S, Majumder D, Jana K, Basu J, Kundu M. Uncovering the role of microRNA671-5p/CDCA7L/monoamine oxidase-A signaling in Helicobacter pylori mediated apoptosis in gastric epithelial cells. Pathogens and Disease, 2023, 81: ftad006 (Impact Factor: 3.3)

39.  Ghosh, S., Paul, S., Halder, S., Shit, M., Karmakar, A., Nandi, JB, Jana, K. and Sinha, C. Trace level CN− measurement by ‘turn-on’ emission using Coumarinyl-Benzothiazolyl Schiff base probe in living and non-living environment. Journal of the Indian Chemical Society 2023,100: p.100957 (Impact Factor: 0.284)

40.  Samanta SK, Maiti K, Halder S, Guria UN, Mandal D, Jana K, Mahapatra AK. A ‘double locked’ ratiometric fluorescent probe for detection of cysteine in a viscous system and its application in cancer cells. Organic & Biomolecular Chemistry. 2023, 21: 575-584 (Impact Factor: 3.890).

41.  S Halder, R Maiti, D Ghosh, K Jana*. The Symbiosis of Circadian Rhythms and Oxidative Stress: Exploring Consequences and Opportunities. Indian J Biological Sciences 2022, 28: 1-16

42.  Giri J, Basu M, Roy S, Misra T, Jana K, Chande A, Ukil A. Translationally Controlled Tumor Protein (TCTP)- Mediated Stabilization of Host Anti-apoptotic Protein MCL-1 Is Critical for Establishment of Infection by Intra-macrophage Parasite Leishmania donovani. The Journal of Immunology 2022, 208: 2540-2548 (Impact Factor: 5.426)

43.  Bhunia S, Halder S, Naskar K, Dutta, B, Sahoo D, Jana K, Sinha, C. Spectrophotometric Determination of Trace Amount of Total Fe II/Fe III and Live Cell Imaging of a Carboxylato Zn (II) Coordination Polymer.  Inorganic Chemistry 2022, 61:19790-19799 (Impact Factor 5.436).

44.  Chandra A, Halder S, Bhunia S, Pal S, Jana K, Sinha C. Zn (II)-dicarboxylato-terpyridyl Coordination Polymer-a ‘Turn on’fluorogenic platform for Al3+ sensing in aqueous medium and life cell imaging. Journal of Molecular Structure 2023, 1275: 134559 (Impact Factor 3.84).

45.  Mandal M, Karak A, Halder S, Banerjee S,  Maiti A,  Jana K, Mahapatra AK, Kar A. A ratiometric styryl bridging triphenylamine-indolinium based fluorescent dye for detection of cyanide with a large emission shift in human breast cancer cells and test strips. Supramolecular Chemistry 2022, 33: 605-615 (Impact Factor 2.4).

46.  Sinha C, Debsharma K, Dey S, Das D, Halder S, Ortega-Castro J, Sarkar S, Dutta B, Maity S, Jana K*, Frontera A, Ray PP. Designing of Zn (II)-isonicotinohydrazido thiophenyl based 2D coordination polymer: structure, augmented photoconductivity and superior biological activity. CrystEngComm 2023, 25: 162-172 (Impact Factor 3.75).

47.  Chatterjee HS, Maity S, Halder S, Ghosh P, Jana K, Mahapatra PK, Sinha C.  Biological activity of non-radical vs. stable radical of a pyridazine-sulfonamide aminophenol-type compound. New Journal of Chemistry 2022, 46, 17951-17957 (Impact Factor 3.92).

48.   Karak A, Mandal M, Halder S, Banerjee S, Banik D, Maiti A, Jana K, Mahapatra AK. Switching to a 'turn-on' fluorescent probe for rapid detection of hydrazine in human breast cancer cells using a test-strip. Analytical Methods 2022, 14: 3652-3660 (Impact Factor: 3.532).

49.  Banerjee S,   Mandal M,  Halder S,   Karak A, Barik D, Jana K,  Mahapatra AK. An ICT-guided ratiometric naphthalene–benzothiazole-based probe for the detection of cyanide with real-time applications in human breast cancer cells. Analytical Methods 2022, 14, 3209-3217 (Impact Factor: 3.532).

51.  Maiti A, Manna SK, Halder S, Mandal M, Karak A, Banik D, Jana K, Mahapatra AK. Benzothiazole-based dual reaction site fluorescent probe for the selective detection of hydrazine in water and live cells. Organic & Biomolecular Chemistry 2022, 20: 4949-4963 (Impact Factor: 3.890).

52.  Ghosal K, Pal S, Ghosh D, Jana K, Sarkar K. In vivo biocompatible shape memory polyester derived from recycled polycarbonate e-waste for biomedical application. Biomaterials Advances 2022, 138: 212961 (Impact Factor: 7.328)

53.  Mandal M, Guria UN, Halder S, Karak A, Banik D, Jana K, Kar A, Mahapatra AK. A dual-channel chemodosimetric sensor for discrimination between hypochlorite and nerve-agent mimic DCP: application on human breast cancer cells. Organic & Biomolecular Chemistry 2022, 20: 4803-4814 (Impact Factor: 3.890).

54.  Sarkar T, Dhar S, Chakraborty D, Pati S, Bose S, Panda AK, Basak U, Chakraborty S, Mukherjee S, Guin A, Jana K, Sarkar DK, Sa G. FOXP3/HAT1 Axis Controls Treg Infiltration in the Tumor Microenvironment by Inducing CCR4 Expression in Breast Cancer. Frontiers in Immunology, 2022, 13: 740588. (Impact Factor: 8.786)

55.  Joardar N, Jana K, SPS Babu. Crude protein fraction with high thioredoxin reductase (TrxR) enzyme activity from filarial parasite Setaria cervi counters lipopolysaccharide (LPS)-induced inflammation in macrophages. Parasitology Research, 2022, 121:1379–1388. (Impact Factor: 2.348)

56.  Joardar N, Bhattacharya R, Halder S, Sen A, Biswas SR, Jana K*, Sinha Babu SP*. Filarial thioredoxin reductase exerts anti-inflammatory effects upon lipopolysaccharide induced inflammation in macrophages. International Journal of Biological Macromolecules, 2021, 193:1379-1390. (Impact Factor: 8.025)

57.  Vemuri SK*, Halder S, Banala RR, Rachamalla HK, Devraj VM, Mallarpu CS, Neerudu UK, Bodlapati R, Mukherjee S, Venkata SGP, Venkata GRA, Thakkumalai M, Jana K* Modulatory Effects of Biosynthesized Gold Nanoparticles Conjugated with Curcumin and Paclitaxel on Tumorigenesis and Metastatic Pathways—In Vitro and In Vivo Studies. International Journal of Molecular Sciences, 2022: 23: 2150. (Impact Factor: 6.208).

58.  Paul S, Maity S, Halder S, Dutta B, Jana S, Jana K, Sinha C. Idiosyncratic recognition of Zn2+ and CN-using Pyrazolyl-Hydroxy-Coumarin scaffold and live cell imaging: Depiction of Luminescent Zn (II)-Metallocryptand. Dalton Transections, 2022, 51: 3198-3212. (Impact Factor: 4.569)

59.  Chandra A, Dutta B, Pal K, Jana K, Sinha C. Designing of an Adipic acid bridged Zn (II) coordination polymer: Synthesis and biological study. Journal of Molecular Structure, 2021, 1243:130923. (Impact Factor: 3.841).

60.  Chakravarty B, Chattopadhyay R, Jana K, Chakraborty P. Female Fertility Clock Closes to Tick around the Age of 43. Journal of Endocrinology and Reproduction 2021; 25: 79-85 (Impact Factor: 1.05).

61.  Bhowmik M, Biswas Sarkar M, Sarkar RK, Dasgupta A, Saha S, Jana K, Sircar G, Gupta Bhattacharya S, Cloning and immune-biochemical analyses on recombinant chymopapain allergen Cari p 2 showing pollen-fruit cross-reaction. Molecular Immunology 2021, 137: 42-51. (Impact Factor: 4.407).

62.  Bhunia S, Dutta B, Pal K, Chandra A, Jana K, Sinha C. Ultra-trace level detection of Ca2+ in aqueous medium by novel Zn (II)-dicarboxylate-pyridyl co-ordination polymers and cell imaging with HepG2 cells. New Journal of Chemistry 2021 45: 13941-13948. (Impact Factor: 3.925).

63.  Joardar N, Shit P, Halder S, Debnath U, Saha S, Misra AK, Jana K*, Sinha Babu SP. Disruption of redox homeostasis with synchronized activation of apoptosis highlights the antifilarial efficacy of novel piperine derivatives: an in vitro mechanistic approach. Free Radical Biology and Medicine 2021, 169: 343-360. (Impact Factor: 8.101).

64.  Adak AK, Dutta B, Ali SA, Pal K, Jana K, Samanta S, Sinha C. Pyrrolo-benzodiazepine fluorophore for trace amount detection of Cu2+ and application in living cells. Journal of Indian Chemical Society 2021; 98:100085. (Impact Factor: 3.196). (Impact Factor: 0.284).

65.  Saha S, Roy S, Dutta A, Jana K, Ukil A. Leishmania donovani targets host transcription factor NRF2 to activate anti-oxidant enzyme HO-1 and transcriptional repressor ATF3 for establishing infection. Infection and Immunity 2021, 89: e00764-20. (Impact Factor: 3.441).

66.  M Das, S Basu, B Banerjee, K Jana, A Sen, G Datta. Renoprotective effect of Capsicum annum against ethanol‐induced oxidative stress and renal apoptosis. Journal of Food Biochemistry 2021, 45: e13325. (Impact Factor: 3.654).

67.  Mazumdar S, Ghosh AK, Dinda M, Das AK, Das S, Jana K, Karmakar P. Evaluation of wound healing activity of ethanol extract of Annona reticulata L. leaf both in vitro and in diabetic mice model. Journal of Traditional & Complementary Medicine 2021, 11: 27-37. (Impact Factor: 4.396).

68.  Karmakar B, Saha B, Jana K, Gupta Bhattachrya S. Identification and biochemical characterisation of Asp36, a new fungal allergen from Aspergillus terreus. The Journal of Biological Chemistry 2020, 295: 17852-864. (Impact Factor: 5.486).

69.  Chatterjee HS, Dutta B, Pal K, Jana K, Mahapatra PK, Sinha C. Synthesis, crystal structure and biological application of a Cu(II) coordination compound of 2-hydroxy-5-methyl-3-(pyridin-3-yliminomethyl)-benzaldehyde. Journal of the Indian chemical Society 2020, 98: 100007. (Impact Factor: 0.284).

70.  Paul S, Dey S, Pal K, Maity S, Jana K, Sinha C. A Fluorogenic Triphenyl‐Amine‐Naphthyl‐Hydrazide Probe Selective for Cu2+ and Cysteine Detection via an ON‐OFF‐ON Logic path with Real Applications. Chemistry Select. 2020, 5: 15233-242. (Impact Factor: 2.307).

71.  Battachrya A, Mukherjee S, Khan P, Banerjee S, Dutta A, Banerjee N, Sengupta D, Basak U, Chakraborty S, Jana K, Sarkar DK, Chatterjee S, Das T. Stemness factors repress SMAR1 to bestow drug resistance in cancer stem cells: Reversal by Aspirin. Science Signalling 2020, 13: eaay6077. (Impact Factor: 9.517).

72.  Saha N, Pal K, Ahmed F, Sepay N, Jana K, Slawin AMZ, Sinha C. Functionalized sulfamethoxazole and its metal complex: structural characterization, antibacterial anti-cancer study of sulfamethoxazole-azo-salicylic acid and its copper (II) complex. Journal of Indian Chemical Society (Spl. Issue: Medicinal Chemistry), 2020; 97:1199-1209. (Impact Factor: 0.284).

73.  Dey S, Maity S, Purkait R, Pal K, Ghosh, P, Jana K, Sinha C. X-ray structure of two Schiff bases: TURN-ON sensing of Fe3+ and Al3+ in the HepG2 Cell line. Analytical Methods 2020, 12: 5485-95. (Impact Factor: 3.532).

74.  S Banerjee, S Mukherjee, A Bhattacharya, U Basak, Chakraborty S, Pal S, Khan P, Jana K, Hazra T, Das T. Pyridoxine enhances chemo-responsiveness of breast cancer stem cells via redox reconditioning. Free Radical Biology and Medicine 2020, 152: 152-165. (Impact Factor: 8.101).

75.  M Basu, P Gupta, A Dutta, K Jana, A Ukil. Increased host ATP efflux and its conversion to extracellular adenosine is crucial for establishing Leishmania infection. Journal of Cell Science 2020, 133: jcs239939. (Impact Factor: 5.235).

76.  K Islam, K Pal, U Debnath, RS Basha, AT Khan, K Jana*, AK Misra*. Anti-cancer potential of (1, 2-dihydronaphtho [2, 1-b] furan-2-yl) methanone derivatives. Bioorganic & Medicinal Chemistry Letters 2020, 30: 127476. (Impact Factor: 2.94).

77.  B Dutta, S Dey, K Pal, S Bera, S Naaz, K Jana, C Sinha, MH Mir. Supramolecular assembly of a 4-(1-naphthylvinyl) pyridine-appended Zn (ii) coordination compound for the turn-on fluorescence sensing of trivalent metal ions (Fe 3+, Al 3+, and Cr 3+) and cell imaging application. New Journal of Chemistry 2020, 44; 13163-13171. (Impact Factor: 3.925).

78.  Dey S, Maity S, Pal K, Jana K, Sinha C. The oxidative dehydrogenation of a coumarinyl scaffold with    copper ion and metal ion detection in human liver cancer cells (HepG2). Dalton Transactions 2019, 48:17818-17830. (Impact Factor: 4.569).

79.  Kumar M, Majumder D, Mal S, Chakraborty S, Gupta P, Jana K, Gupta UD, Ghosh Z, Kundu M, Basu J. ATF3 modulates the macrophage immune response to Mycobacterium tuberculosis infection via reciprocal regulation of inflammatory genes and lipid body formation. Cellular Microbiology 2019, 22: e13142. (Impact Factor: 4.41).

80.  Chandra A, Das M, Pal K, Jana S, Dutta B, Ray PP, Jana K, Sinha C. Three-Dimensional-Coordination Polymer of Zn(II)-Carboxylate: Structural Elucidation, Photoelectrical Conductivity, and Biological Activity. ACS Omega 2019, 4:17649-17661. (Impact Factor: 4.132).

81.  Banerjee SK, Lata S, Sharma AK, Bagchi S, Kumar M, Sahu SK, Sarkar D, Gupta P, Jana K, Gupta UD, Singh R, Saha S, Basu J, Kundu M. The sensor kinase MtrB of Mycobacterium tuberculosis regulates hypoxic survival and establishment of infection. The Journal of Biological Chemistry 2019, 52: 19862-19876. (Impact Factor: 5.486).

82.  Banerjee B, Chakraborty S, Chakraborty P, Ghosh D, Jana K*. Protective effect of resveratrol on benzo (a) pyrene induced dysfunctions of steroidogenesis and steroidogenic acute regulatory gene expression in Leydig cells. Frontiers in Endocrinology 2019, 10: 272. (Impact Factor: 6.055).

83.  Manna T, Pal K, Jana K*, Misra AK. Anti-cancer potential of novel glycosylated 1, 4-substituted triazolylchalcone derivatives. Bioorganic & Medicinal Chemistry Letters 2019, 29:126615. (Impact Factor: 2.94).

84.  Dutta B, Pal K, Jana K, Sinha C, Mir MH. Fabrication of a Zn (II)‐Based 2D Pillar Bilayer Metal‐Organic Framework for Antimicrobial Activity. Chemistry Select 2019, 4: 9947-9951. (Impact Factor: 2.307).

85.  Dey S, Pal K, Jana K, Sinha C. Effect of ‐OMe Substituent on Salicylaldehyde Schiff Base to Influence the Zn2+ Sensitivity and the Cancer Cell Line Imaging. Chemistry Select 2019, 4:7932-7935. (Impact Factor: 2.307).

86.  Bhaumik I, Pal K,Debnath U, Karmakar P, Jana K*, Misra AK. Natural product inspired allicin analogs as novel anti-cancer agents. Bioorganic Chemistry 2019, 86: 259-272. (Impact Factor: 5.307).

87.  Dey S, Purkait R, Pal K, Jana K, Sinha C. Aggregation-Induced Emission-Active Hydrazide-Based Probe: Selective Sensing of Al3+, HF2–, and Nitro Explosives. ACS Omega 2019, 4: 8451-8464. (Impact Factor: 4.132).

88.  Debnath U, Mukherjee S,Joardar N, Sinha Babu SP, Jana K, Misra AK. Aryl quinolinyl hydrazone derivatives as anti-inflammatory agents that inhibit TLR4 activation in the macrophages. European Journal of Pharmaceutical Sciences 2019, 134: 102-115. (Impact Factor: 5.112).

89.  Saha S, Basu M, Guin S, Gupta P, Mitterstiller AM, Weiss G, Jana K, Ukil A. Leishmania donovani Exploits Macrophage Heme Oxygenase-1 To Neutralize Oxidative Burst and TLR Signaling–Dependent Host Defence. Journal of Immunology 2019, 202:827-840. (Impact Factor: 5.426).

90.  Laha D, Pal K, Chowdhuri AR, Parida PK, Sahu SK, Jana K, Karmakar P. Fabrication of curcumin-loaded folic acid-tagged metal organic framework for triple negative breast cancer therapy in in vitro and in vivo systems. New Journal of Chemistry 2019; 43: 217-229. (Impact Factor: 3.925).

91.  Datta SP, Jana K, Mondal A, Ganguly S, Sarkar S. Multiple paralogues of α-SNAP in Giardia lamblia exhibit independent subcellular localization and redistribution during encystation and stress. Parasites &Vectors 2018; 11:539. (Impact Factor: 4.047).

92.  Roy A, Sarker S, Upadhyay P, Pal A, Adhikary A, Jana K*, Ray M. Methylglyoxal at metronomic doses sensitizes breast cancer cells to doxorubicin and cisplatin causing synergistic induction of programmed cell death and inhibition of stemness. Biochemical Pharmacology. 2018; 156:322-339. (Impact Factor: 6.1).

93.  Datta C, Subuddhi A, Kumar M, Lepcha TT, Chakraborty S, Jana K, Ghosh Z, Mukhopadhyay AK, Basu J, Kundu M. Genome-wide mRNA-miRNA profiling uncovers a role of the microRNA miR-29b -1-5p/PHLPP1 signalling pathway in Helicobacter pylori-driven matrix metalloproteinase production in gastric epithelial cells. Cellular Microbiology, 2018; 20: e12859. (Impact Factor: 4.41).

94.  Pal K, Laha D, Parida PK, Jana K, Karmakar P. An In Vivo Study for Targeted Delivery of Curcumin in Human Triple Negative Breast Carcinoma Cells Using Biocompatible PLGA Microspheres Conjugated with Folic Acid. Journal of Nanoscience and Nanotechnology, 2019; 19: 3720-3733. (Impact Factor: 1.354).

95.  Das M, Banerjee B, Sen A, Basu S, Jana K, Dutta G. Hepatoprotective Effects of Green Capsicum annum against Ethanol Induced Oxidative Stress, Inflammation and Apoptosis in Rats. Journal of Ethnopharmacology 2018; 227: 69-81. (Impact Factor: 5.195).

96.  Parida, PK, Mahato B, Santra A, Chakraborty S, Gosh Z, Raha, S. Misra AK, Biswas K, Jana K*. Inhibition of cancer progression by a novel trans-stilbene derivative of Resveratrol by interfering with microtubule dynamics, driving G2/M arrest and p53-dependent apoptosis. Cell Death & Disease, 2018; 9: 448. (Impact Factor: 9.685).

97.  Ghosh R, Banerjee B, Das T, Jana K, Choudhury SM. Antigonadal and endocrine-disrupting activities of lambda cyhalothrin in female rats and its attenuation by taurine. Toxicology & Industrial Health. 2018; 34:146-157. (Impact Factor: 2.273).

98.  Sarkar MB, Sircar G, Ghosh N, Das AK, Jana K, Dasgupta A, Bhattacharya SG. Cari p 1, a Novel Polygalacturonase Allergen from Papaya Acting as Respiratory and Food Sensitizer. Frontier in Plant Science. 2018, 9: 823. (Impact Factor: 6.627).

99.  Sarkar P, Jana K, Sikdar SR. Overexpression of biologically safe Rorippaindica defensin enhances aphid tolerance in Brassica juncea. Planta 2017, 246:1029-1044. (Impact Factor: 4.504).

100.          Gucchait A, Joardar N, Parida PK, Yesuvadian R, Sinha Babu SP, Jana K*, Misra AK. Development of novel anti-filarial agents using carbamo(dithioperoxo)thioate derivatives
European Journal of Medicinal Chemistry 2017; 143:598-610. (Impact Factor: 7.088).

101.          Roy A, Ahir M, Bhattacharya S, Parida PK, Adhikary A, Jana K*, Ray M. Induction of Mitochondrial Apoptotic Pathway in Triple Negative Breast Carcinoma Cells by Methylglyoxal via Generation of Reactive Oxygen Species. Molecular Carcinogenesis 2017, 56:2086-2103. (Impact Factor: 5.139).

102.          Gucchait A, Jana K, Misra AK. Convenient preparation of thioglycomimetics: S-glycosyl sulfenamides, sulfinamides and sulphonamides. RSC Advances 2017, 7: 32478-32487. (Impact Factor: 3.361).

103.          Sahu SK,  KumarM, Banerjee S,Banerjee SK, Kumar R, Gupta P, Jana K,  Gupta UD, Ghosh Z, Kundu M, Basu J. miR-26a-KLF4 and CREB-C/EBP beta regulate innate immune signalling, the polarization of macrophages and the trafficking of Mycobacterium tuberculosis to lysosomes during infection. PLoS Pathogen 2017, 13: e1006410. (Impact Factor: 6.51).

104.          Dutta A, Dhara D, Parida PK, Si A, Yesuvadian, R, Jana K*, Misra AK. C-Glycosylated cinnamoylfuran derivatives as novel anticancer agents. RSC Advances 2017, 7: 28853-28864. (Impact Factor: 4.036).

105.          Banerjee B, Nandi P, Chakraborty S, Raha S, Sen PC, Jana K*. Resveratrol ameliorates benzo(a)pyrene induced testicular dysfunction and apoptosis through p38 MAPK/ATF2/iNOS signalling. The Journal of Nutritional Biochemistry 2016, 34: 17-29. (Impact Factor: 6.117).

106.          Banerjee A, Sanyal S, Dutta S, Chakraborty P, Das PP, Jana K, Vasudevan M, Das C, Dasgupta D. The plant alkaloid chelerythrine binds to chromatin, alters H3K9Ac and modulates global gene expression. Journal of Biomolecular Structure and Dynamics. 2016; 5:1-9. (Impact Factor: 5.235).

107.          Banerjee B, Nandi P, Chakraborty S, Raha S, Sen PC, Jana K*. Curcumin and resveratrol synergistically prevent benzo(a)pyrene induced male germ cell apoptosis by modulating MAPKs and p53. Frontiers in Pharmacology 2016; 7: 245. (Impact Factor: 5.988).

108.          Banerjee, S, Kumar, M, Alokam, R, Sharma, AK, Chatterjee A, Kumar R, Sahu SK, Jana K, Singh R, Yogeeswari P, Sriram D, Basu J, Kundu M. Targeting multiple response regulators of Mycobacterium tuberculosis augments the host immune response to infection. Scientific Reports 2016; 6: 25851. (Impact Factor: 4.996).

109.          Ghosh, R, Pradhan A, Maity P, Jana K, Maiti Choudhury S. Lipid peroxidative damage, alteration in antioxidant status and morphological changes in rat erythrocytes on Lambda-cyhalothrin exposure and its attenuation by taurine. Toxicology and Environmental Health Sciences. 2016, 8: 315-326. (Impact Factor: 1.708).

110.          Gucchait A, Jana M, Jana K, Misra AK. Preparation of glycosyl thiourea derivatives from glycosyl azides using sulfamic acid and sodium iodide in one-pot. Carbohydrate Research. 2016, 434: 107-112. (Impact Factor: 2.975).

111.          Dinda, M., Chakraborty, M., Ganguly, D., Dasgupta, U., Dutta, A., Jana, K., Karmakar, P. The water fraction of Calendula officinalis hydroethanol extract stimulates in vitro and in vivo proliferation of dermal fibroblasts in wound healing. Phytotherapy Research 2016; 30:1696-1707. (Impact Factor: 6.388).

112.          Roy P, Dhara D, Parida PK, Kar RK, Bhunia A, Jana K*., Misra AK. C-cinnamoyl glycosides as a new class of anti-filarial agents. European Journal of Medicinal Chemistry. 2016; 114:308-17. (Impact Factor: 7.088).

113.          Mukherjee N, Parida PK, Santra A, Ghosh T, Dutta A, Jana K, Misra AK, Sinha Babu SP. Oxidative stress plays major role in mediating apoptosis in filarial nematode Setaria cervi in the presence of trans-stilbene derivatives. Free Radical Biology & Medicine. 2016; 93:130-44. (Impact Factor: 8.101).

114.          Kumar R, Sahu SK, Kumar M, Jana K, Gupta P, Gupta UD, Kundu M, Basu J. MicroRNA 17-5p regulates autophagy in Mycobacterium tuberculosis-infected macrophages by targeting Mcl-1 and STAT3. Cellular Microbiology 2016; 18:679-91. (Impact Factor: 4.41).

115.          Halder P, Kumar R, Jana K, Chakraborty S, Ghosh Z, Kundu M, Basu J. Gene expression profiling of Mycobacterium tuberculosis Lipoarabinomannan-treated macrophages: A role of the Bcl-2 family member A1 in inhibition of apoptosis in mycobacteria-infected macrophages. IUBMB Life 2015; 67:726-36. (Impact Factor: 4.709).

116.          Kumar M, Sahu SK,  Kumar R,  Subuddhi A,  Maji RK, Jana K,  Gupta P, Raffetseder J, Lerm M., Ghosh Z, van Loo G, Beyaert R, Gupta UD, Kundu M, Basu J. MicroRNA let-7 modulates the Immune Response to Mycobacterium tuberculosis Infection via Control of A20, an Inhibitor of the NF-κB Pathway. Cell Host & Microbe 2015, 17:345-56. (Impact Factor: 31.316).

117.          Ray M, Rai N, Jana K, Ghatak S, Basu A, Mustafi SB, Raha S. Beta catenin is degraded by both caspase-3 and proteasomal activity during resveratrol-induced apoptosis in HeLa cells in a GSK3β-independent manner. Indian J Biochem Biophysics 2015, 52:7-13. (Impact Factor: 1.918).

118.          Banerjee A, Sanyal S, Majumder P, Chakraborty P, Jana K, Das C, Dasgupta D. Recognition of chromatin by the plant alkaloid, ellipticine as a dual binder. Biochemical and Biophysical Research Communications. 2015, 462:352-57. (Impact Factor: 3.575).

119.          Nandi P, Banerjee B, Ghosh S, Chakrabarty A, Jana K and Sen PC. Involvement of Nifetepimine in Motility and Capacitation of Caprine Spermatozoa. American Journal of Experimental Biology 2014, 1: 61-84.

120.          Banerjee A, Sanyal S, Kulkarni KK, Jana K, Roy S, Das C, Dasgupta D. Anticancer drug mithramycin interacts with core histones: An additional mode of action of the DNA groove binder. FEBS Open Bio 2014, 4: 987-95. (Impact Factor: 2.792).

121.          Firdaus SB, Ghosh A, Chattyopadhyay A, Jana K, Bandyopadhyay D. Protective effect of antioxidant rich aqueous curry leaf (Murrayakoenigii) extract against gastro-toxic effects of piroxicam in male Wistar rats. Toxicology Reports 2014; 1: 987-1003. (Impact Factor: 4.81).

122.          Jana K*, Dutta A, Chakraborty P, Manna I, Firdaus SB, Bandyopadhyay D, Chattopadhyay R, Chakravarty B. α- lipoic acid and N-acetylcysteine protects intensive swimming exercise mediated germ cell depletion, pro-oxidant generation and alteration of steroidogenesis in rat testis. Molecular Reproduction & Development 2014; 8: 833-50. (Impact Factor: 3.113).

123.          Parida PK, Sau A, Ghosh T, Jana K*, Biswas K, Raha S, & Misra AK. Synthesis and evaluation of triazole linked glycosylated 18 beta-glycyrrhetinic acid derivatives as anticancer agents. Bioorganic & Medicinal Chemistry Letters 2014, 24:3865-8. (Impact Factor: 2.94).

124.          Firdaus, SB, Ghosh A, Chattyopadhyayb A, Jana K, Bandyopadhyay D. A combination of aqueous curry (Murrayakoenigii) leaf extract and melatonin protects against piroxicam induced gastric ulcer in male albino rats: Involvement of antioxidant mechanism(s). Journal of Pharmacy Research 2014, 8: 428-436. (Impact Factor: 0.784).

125.          Roy A, Roy M, Jana K*. Cancer Stem Cells, Wnt, Hedgehog and Notch Signaling, the Role of Dietary Phytochemicals: New Insights for Cancer Therapy. Translational Medicine 2014, S3: e125. (Impact Factor: 5.03). 

126.          Banerjee A., Majumder P., Singh J., Jana K, Das C., Dasgupta, D. The DNA intercalators, ethidium bromide and propidium iodide, bind to core histones. FEBS Open Bio, 2014, 15: 251-9. (Impact Factor: 2.792).

127.          Chakraborty, P., Goswami, S.K., Rajani, S., Sharma, S., Kabir, S.N., Chakravarty BN., Jana, K*. Recurrent pregnancy loss in polycystic ovary syndrome: role of hyper-homocysteinemia and insulin resistance. PLoS One 2013; 8: e64446. (Impact Factor: 3.752).

128.          Jana, K*, Banerjee, B. & Parida P.K. Caspases: A Potential Therapeutic Targets in the Treatment of Alzheimer’s disease. Translational Medicine 2013; S2: 006. (Impact Factor: 5.03).

129.          Chakraborty, P., Goswami, S.K., Rajani, S., Sharma, S., Kabir, S.N., Chakravarty B.N., & Jana, K*. Altered trace mineral milieu might play an aetiological role in the pathogenesis of polycystic ovary syndrome. Biology of Trace Element Research 2013; 152: 9-15. (Impact Factor: 4.081).

130.          Basu, A., Mukherjee, D., Ghosh, A.K., Mitra E., Firdaus, S.B., Ghosh, D., Jana, K., Bandyopadhyay, A., Chattopadhyay A. And Bandyopadhyay D. Melatonin augments the protective effects of aqueous leaf homogenate of tulsi (ocimum sanctum l.) against piroxicam-induced gastric ulceration in rats. Asian Journal of Pharmaceutical and Clinical Research. 2013; 6: 123-132. (Impact Factor: 0.701)

131.          Ghosh, D., Firdaus, S.B, Mitra, E., Dey, M., Chattopadhyay, A., Pattari, S.K., Dutta S., Jana, K. & Bandyopadhyay D. Hepatoprotective activity of aqueous leaf extract of Murrayakoenigii against lead-induced hepatotoxicity in male wistar rat. International Journal of Pharmacy and Pharmaceutical Sciences 2013; 5: 285-295. (Impact Factor: 2.327).

132.          Basu, A., Mitra, E., Dey, M., Chattopadhyay, A., Pattari, S.K., Dutta S.K., Jana, K. & Bandyopadhyay, D. Aqueous tulsi leaf (ocimum sanctum l.) extract protects against piroxicam-induced gastric ulceration in rats: involvement of antioxidant mechanisms. International Journal of Pharmacy and Pharmaceutical Sciences 2013; 5: 438-447. (Impact Factor: 2.327).

133.          Ghosh D, Firdaus, SB, Mitra, E, Dey, M, Chattopadhyay, A, Pattari, SK., Dutta S., Jana, K. & Bandyopadhyay D. Aqueous leaf extract of Murrayakoenigii protects against lead-induced cardio toxicity in male wistar rats. International Journal of Phytopharmacology 2013; 4: 119-132. (Impact Factor: 1.02).

134.          Ghosh, D, Firdaus, S.B, Mitra, E., Dey, M., Chattopadhyay, A., Pattari, S.K., Dutta S., Jana, K. & Bandyopadhyay D. Ameliorative effect of curry leaf aqueous extract against lead acetate induced oxidative stress in rat kidneys. International Journal of Pharmacy and Pharmaceutical Sciences 2013; 5:546-556. (Impact Factor: 2.327).

135.          Jana, K*, Samanta, P.K. Clinical evaluation of non-surgical Sterilization of male Cats with Single intra-testicular Injection of Calcium Chloride. BMC Veterinary Research 2011; 7: 39. (Impact Factor: 2.792).

136.          Nandi, P, Charteerjee, S., Jana, K. & Sen, P.C. Role of a 14 kD sperm protein p14 in maturation, acrosome reaction and capacitation of caprine spermatozoa. PLoS One 2012; 7: e30552. (Impact Factor: 3.752).

137.          Kumar, R., Halder, P., Sahu, S.K., Kumar, M., Kumari, M., Jana, K., Ghosh, Z., Sharma, P., Kundu, M. & Basu, J. Identification of a novel role of ESAT-6-dependent miR-155 induction during infection of macrophages with Mycobacterium tuberculosis. Cellular Microbiology 2012; 14:1620-31. (Impact Factor: 4.41).

138.          Jana, K*. Jana, N., De, DK, Guha SK. Ethanol induces mouse spermatogenic cell apoptosis in vivo through over expression of Fas/Fas-L, p53 and caspase-3 along with cytochrome c translocation and glutathione depletion. Molecular Reproduction & Development 2010; 77, 820-833. (Impact Factor: 3.113).

139.          Jana K*, Samanta, P.K. & De, D.K. Nicotine diminishes testicular gametogenesis, steroidogenesis and steroidogenic acute regulatory protein expression in adult albino rats: possible influence on pituitary gonadotropins and alters testicular antioxidant status. Toxicological Sciences 2010; 116: 647-659. (Impact Factor: 4.849).

140.          Jana, K*, Yin, P., Schiffer, X., Grammas, P., Stocco, D.M. & Wang, X.J. Effect of Chrysin on steroidogenesis and steroidogenic acute regulatory gene expression in mouse MA-10 tumor Leydig cells. Journal of Endocrinology 2008, 197: 315-323. (Impact Factor: 4.669).

141.          Jana, K*, Manna, I. & Samanta, P.K. Protective effect of sodium selenite and zinc sulfate on intensive swimming exercise- induced testicular gamatogenic and steroidogenic disorders in mature male rats. Applied Physiology Nutrition and Metabolism2008; 33: 903-914. (Impact Factor: 3.016).

142.          Jana, K. & Samanta, P.K. Strilization of male stray dog by single intratesticular injection of calcium chloride. Contraception 2007; 75: 390-400. (Impact Factor: 3.375).

143.          Jana, K*, Samanta, S. &Samanta, P.K. The possible estrogenic mode of action of sodium arsenite on pituitary- testicular activities in adult albino rats. Reproductive Biology and Endocrinology 2006, 4: 9- 22. (Impact Factor: 5.426).

144.          Samanta, P.K., Manna, I. & Jana, K. Effect of L - ascorbic acid supplementation on testicular oxidative stress and reproductive dysfunctions in rats exposed to intensive exercise stress. Reproductive Medicine and Biology 2006, 5: 145-153. (Impact Factor: 4.009).

145.          Jana, K. & Samanta P.K. Evaluation of single intra-testicular injection of calcium chloride for non-surgical sterilization in adult albino rats. Contraception 2006, 73: 289-300. (Impact Factor: 3.375).

146.          Jana, K., Ghosh, D. & Samanta, P.K. Evaluation of single Intra-testicular injection of calcium chloride for non-surgical sterilization of male Black Bengal goats. (Capra-hircus): A dose dependent study. Animal Reproduction Science 2005; 86: 89-108. (Impact Factor: 2.22).

147.          Manna, I., Jana, K. & Samanta, P.K. Effect of different intensities of Swimming Exercise on testicular oxidative stress and reproductive dysfunctions in mature male albino Wister rats. Indian Journal of Experimental Biology 2004; 42: 816-822. (Impact Factor: 0.944).

148.          Manna, I., Jana, K. & Samanta, P.K. Intensive swimming exercise induced oxidative stress and reproductive dysfunctions in male wistar rats: Protective role of α- tocoferol succinate. Canadian Journal of Applied Physiology2004, 29: 172- 185. (Impact Factor: 3.016).

149.          Manna, I., Jana, K. & Samanta PK. Effect of intensive exercise-induced testicular gametogenic and steroidogenic disorders in matured male wistar strain rats: A correlative approach to oxidative stress. Acta Physiologica 2003; 178: 33-40. (Impact Factor: 7.523).

150.          Jana, K., Samanta, P.K. & Ghosh, D. Dose dependent response to an intra-testicular injection of calcium chloride for induction of chemosterilization in adult albino rats. Veterinary Research Communications 2002; 26: 651-663. (Impact Factor: 2.816).

Book Chapters:

 

1.      Jana, K*. & Sen, P.C. Environmental Toxicants Induced Male Reproductive Disorders: Identification and Mechanism of Action. Toxicity & Drug Testing. Edited by William Acree, In Tech Publication, Croatia, 2012, pp. 473-518.

2.      Goswami, A., Sen, P., Jana, K. & Raha, S. Involvement of Caspases in Neurodegenaration and Stroke. Proteases and Neural Disorders. Role of Proteases in Cellular Dysfunction, Edited by Sajal Chakraborty and Naranjan S Dhalla, Springer Publisher, New York, USA.2013, 8: pp 47-66.

3.      Joardar N, Mukherjee N, Halder S, Jana K*, Sinha Babu SP. Triggering the downstream apoptotic signal inside human parasitic organisms demonstrates a promising approach for anti-parasitic drug development: A mechanistic perspectives. Advances in Protein Chemistry and Structural Biology, Apoptosis in Health & Disease, 1st Edition, Edited by Rossen Donav, Elesevier Inc. Academic Press, Cambridge, MA, United States 2021, 125:193-213

4.      Halder S & Jana K*. Reactive Oxygen Species acts as a double-edged swords in cancer progression and therapy.  The Role of Reactive Oxygen Species in Health and Disease, Edited by K. Jana, NOVA Publishers, USA, 2023. 

5.      Halder S, Joarder N, Maiti R, Sinhababu SP, Jana K*. The interplay between endoplasmic reticulum stress mediated ROS generation and apoptosis in human diseases. The Role of Reactive Oxygen Species in Health and Disease, Edited by K. Jana, NOVA Publishers, USA, 2023.

6.      Joarder N, Halder S, Sinhababu SP, Jana K*.  Role of misfolded proteins on oxidative stress mediated neurodegeneration” The Role of Reactive Oxygen Species in Health and Disease, Edited by K. Jana, NOVA Publishers, USA, 2023.

7.      Majumder C, Manna A, Halder S, Jana K*. Mechanism of mitochondrial reactive oxygen species (mtROS) generation and its role in apoptosis, pathogenesis of inflammatory and neurodegenerative disorders. The Role of Reactive Oxygen Species in Health and Disease, Edited by K. Jana, NOVA Publishers, USA, 2023.

8.      Manna A, Majumder C, Halder S, Jana K*. Reactive oxygen species: its role in aging of the brain and neurodegenerative disease.  The Role of Reactive Oxygen Species in Health and Disease, Edited by K. Jana, NOVA Publishers, USA, 2023.

9.      Halder S, Jana K*. Targeting Reactive Oxygen Species (ROS) in the prevention of Non-Communicable Diseases: Promise and limitations of antioxidant therapy. The Role of Reactive Oxygen Species in Health and Disease, Edited by K. Jana, NOVA Publishers, USA, 2023.

10.  Halder S, Jana K*. Apoptosis: Intricate connections in cell death pathways and disease implications. Apoptosis and Human Health: Understanding Mechanistic and Therapeutic Potential. Edited by K. Jana, Springer Nature Singapore, 2024.

11.  Halder, Patra P, Ghosh P, Mondal N, Chini DS, and Jana K*. Apoptosis: A Controlled Cell’s Fate. Apoptosis and Human Health: Understanding Mechanistic and Therapeutic Potential. Edited by K. Jana, Springer Nature Singapore, 2024.

12.  Halder S, Manna A and Jana K*. Apoptosis: Novel insights into the role of death receptors and caspases in cell fate. Apoptosis and Human Health: Understanding Mechanistic and Therapeutic Potential. Edited by K. Jana, Springer Nature Singapore, 2024.

13.  Bar S, Dhara S, Halder S, Jana K*, Ghorai SK. Apoptosis: Mechanisms and Clinical Implications. Apoptosis and Human Health: Understanding Mechanistic and Therapeutic Potential. Edited by K. Jana, Springer Nature, Singapore, 2024.

14.  Majumder C, Manna A, Halder S and, Jana K*. Apoptosis and Mitochondria: Cell death mechanisms. Apoptosis and Human Health: Understanding Mechanistic and Therapeutic Potential. Edited by K. Jana, Springer Nature, Singapore, 2024.

15.  Halder S, Jana S, Majumder C and Jana K*. Apoptosis: ER stress and Disease pathology. Apoptosis and Human Health: Understanding Mechanistic and Therapeutic Potential. Edited by K. Jana, Springer Nature, Singapore, 2024.

16.  Halder S, Jana S, Manna A and Jana K*. Apoptosis: Oxidative stress and Antioxidants. Apoptosis and Human Health: Understanding Mechanistic and Therapeutic Potential. Edited by K. Jana, Springer Nature, Singapore, 2024.

17.  Jana S, Halder S, Bhattacharya A, Bhattacharya MK and Jana K. Mechanism of PANoptosis and its implications in cancer progression and treatment.  Apoptosis and Human Health: Understanding Mechanistic and Therapeutic Potential. Edited by K. Jana, Springer Nature, Singapore, 2024.

18.  Bar S, Dhara S, Pal K, Halder S, Jana K* and Ghorai SK. Role of Apoptosis in diabetes: Therapeutic targets and strategies. Apoptosis and Human Health: Understanding Mechanistic and Therapeutic Potential. Edited by K. Jana, Springer Nature Singapore, 2024.

19.  Jana S, Halder S, Bhattacharya A, Bhattacharya MK and Jana K*. Role of Apoptosis in viral infections with special reference to Covid 19: Therapeutic targets and strategies. Apoptosis and Human Health: Understanding Mechanistic and Therapeutic Potential. Edited by K. Jana, Springer Nature, Singapore, 2024.

20.  Pal D, Halder S, Ghosh D and Jana K*. Role of Apoptosis in male Infertility: Therapeutic targets and strategies. Apoptosis and Human Health: Understanding Mechanistic and Therapeutic Potential. Edited by K. Jana, Springer Nature, Singapore, 2024.

21.  Manna A, Majumder C, Halder S, Jana K*. Role of Apoptosis in Aging: Therapeutic Targets and Strategies. Apoptosis and Human Health: Understanding Mechanistic and Therapeutic Potential. Edited by K. Jana, Springer Nature, Singapore, 2024.

22.  Halder S, Jana K*. Apoptosis and cancer immunotherapy: Current mechanisms and emerging strategies. Apoptosis and Human Health: Understanding Mechanistic and Therapeutic Potential. Edited by K. Jana, Springer Nature, Singapore, 2024.

23.  Halder S, Brahmachari G and Jana K*.  Molecular signaling of prostate cancer chemoprevention by natural products: current perspectives and future directions. In: Discovery and Development of Anti-Prostate Cancerous Agents from Natural Products, Natural Product Drug Discovery Series, 6th Edition, Edited by Brahmachari G, Elsevier, USA. 2025.

 

 Book:

 

Editor: Dr. Kuladip Jana

 

1.     Jana K. (Editor) The Role of Reactive Oxygen Species in Health and Disease by NOVA Publishers, USA, 2024 ISBN: 979-8-89113-283-2

 

Jana K. (Editor) Apoptosis and Human Health: Understanding Mechanistic and Therapeutic Potential by Springer Nature, Singapore, 2024. (In Press), ISBN: 9819779049.


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Recognition:

  • International Travel Award from ACC&D (Portland, Oregeon, U.S.A.), 2010
  • DST-First Track Young Scientist Scheme Award, 2010
  • Young Investigator Award from Parsemus Foundation (San Francisco, California, USA) , 2011
  • ACC&D (Portland, Oregeon, U.S.A.) International Travel Award, 2013
  • Young Scientist Award from Parsemus Foundation (Berlley, California, USA) , 2014
  • Outstanding Scientist Award from Venus International Foundation, India., 2015
  • Fellow of “Scholars Academic and Scientific Society” (FSASS), 2021
  • Fellow of Reproduction & Endocrinology (FRE) from SRBCE, 2021
  • Fellow of National Environmental Science Academy (FNESA), 2021
  • Prof. K. C. Bose Gold Medal Award from NESA, New Delhi, 2024

Teaching:


Special paper classes in Endocrinology & Reproductive Physiology/ Biochemistry (Cell signalling, hormone action, signal transduction, cancer signalling and Immunology) and Environmental Science (Toxicology and pharmacology, Reproductive and Endocrine Disorders etc.) of M.Sc. (Physiology) students of University of Calcutta as well as taking classes of Integrated M.Sc.-Ph.D. courses at Bose Institute. 


Students:

Image Name Designation Department Campus Contact number Email

Former:

Name of group Members

Pravat Kumar Parida, CSIR-SRF

Bhaswati Banerjee, SRF

Anirban Ray, UGC-SRF

Ananya Dutta, SRF

Kunal Pal, CSIR-JRF

Dr. Dipranjan Laha, DBT-RA

Arin Gucchait, CSIR-JRF


 


Group News:

The students who are creative, highly motivated & willing to work in a multidisciplinary scientific projects with a very keen interest to work in Molecular Endocrinology/Reproductive Medicine/Cancer Biology/Toxicology/Animal Biotechnology/Molecular Medicine may contact directly at kuladip@jcbose.ac.in/kuladip_jana@yahoo.com/kuladip.jana@gmail.com


or may call me at 9007042850/9007067720