Subhrangsu Chatterjee

Subhrangsu Chatterjee
Associate Professor

Previous appointments:

Postdoctoral Fellow, Department of Biochemistry, University of Alberta, Alberta, Canada (2008-2011)

Ramanujan Fellow (DST, Govt of India), Department of Biophysics, Bose Institute, Kolkata (2011-2016)

Associate Professor, Department of Biophysics, Bose Institute, Kolkata (2016-till date)

Research interests:

The main objective of our research is to understand the supercoiling of DNA structure in the chromosome and try to cultivate the importance of nucleic acid structural dynamics and breathing in a conformational hyperspace which can augment or deplete tumorigenesis. 

Contact:

Address: Department of Biophysics
Centenary Campus
Bose Institute
P-1/12 C.I.T. Scheme VII-M
Kolkata - 700054, India
E-Mail: subhro_c[at]jcbose.ac.in
Phone: +91-33-25693340

Research:

Publications:

Selected Publication: (2011-2018)

1. Site-specific Amino Acid Substitution in Dodecameric Peptides Determines the Stability and Unfolding of c-MYC Quadruplex Promoting Apoptosis in Cancer Cells. Pallabi Sengupta1†, Nilanjan Banerjee1†, Tanaya Roychowdhury2, Anindya Dutta1, Samit Chattopadhyay2, and Subhrangsu Chatterjee*( Nucleic Acid Research, 2018, accepted) IF=11.56

2. Spatial Position Regulates Power of Tryptophan: Discovery of a Major-Groove-Specific.Bhunia D, Mondal P, Das G, Saha A, Sengupta P, Jana J, Mohapatra S, Chatterjee S, Ghosh S. J Am Chem Soc. 2018 Feb 7;140(5):1697-1714 IF=14.3

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2. LINCRNA00273 promotes cancer metastasis and its G-Quadruplex promoter can serve as a novel target to inhibit cancer invasiveness Samarjit Jana2,*, Jagannath Jana1,*, Kartick Patra2, Soma Mondal1, Jyotsna Bhat1, Arnab Sarkar2, Pallabi Sengupta1, Anindya Biswas3, Meghomukta Mukherjee1, Satya Prakash Tripathi5, Rahul Gangwal5, Joyita Hazra6, Abhay T. Sangamwar7 Gopeswar Mukherjee4, Shamee Bhattacharjee2*, Deba Prasad Mandal2* and Subhrangsu Chatterjee*. Oncotarget , 2017 Nov 17;8(66):110234-110256 IF=5.4

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3. G-Quadruplex surveillance in BCL-2 gene: a promising therapeutic intervention in cancer treatment. Sengupta, Pallabi; Chattopadhyay, Samit; Chatterjee, Subhrangsu. Drug Discovery, Today (2017), 22(8), 1165-1186.
IF=6.7


4. Restriction of telomerase capping by short non-toxic peptides via arresting telomeric G-quadruplex 
Jana, Jagannath; Sengupta, Pallabi; Mondal, Soma; Chatterjee, Subhrangsu. RSC Advances (2017), 7(34), 20888-20899.IF=3.4

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5. Chelerythrine down regulates expression of VEGFA, BCL2 and KRAS by arresting G-Quadruplex structures at their promoter regions. 
Jana, Jagannath; Mondal, Soma; Bhattacharjee, Payel; Sengupta, Pallabi; Roychowdhury, Tanaya; Saha, Pranay; Kundu, Pallob; Chatterjee, Subhrangsu. Scientific Reports (2017), 7, 40706. IF=5.4

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6. G-actin guides p53 nuclear transport: potential contribution of monomeric actin in altered localization of mutant p53
. Saha, Taniya; Guha, Deblina; Manna, Argha; Panda, Abir Kumar; Bhat, Jyotsna; Chatterjee, Subhrangsu; Sa, Gaurisankar. Scientific Reports (2016), 6, 32626.IF=5.4


7. Nuclear matrix-associated protein SMAR1 regulates alternative splicing via HDAC6-Mediated deacetylation of Sam68 
Kiran Kumar Nakka, Nidhi Chaudhary, Shruti Joshi, Jyotsna Bhat, Subhrangsu Chatterjee, Renu Malhotra, Abhijit De, Manas Kumar Santra, F. Jeffrey Dilworth and Samit Chattopadhyay* Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):E3374-83)IF=9.8


8
In Silico Screening and Binding Characterization of Small Molecules toward a G-Quadruplex Structure Formed in the Promoter Region of c MYC Oncogene. Bhat J, Mondal S, Sengupta P, Chatterjee S. ACS Omega. 2017 Aug 31;2(8):4382-4397. doi: 10.1021/acsomega.6b00531.

9. Plant Alkaloid Chelerythrine Induced Aggregation of Human Telomere Sequence-A Unique Mode of Association between a Small Molecule and a Quadruplex. Ghosh S, Jana J, Kar RK, Chatterjee S*, Dasgupta D*. Biochemistry. 2015 Feb 3;54(4):974-86. doi: 10.1021/bi501117x. Epub 2015 Jan 21 IF= 3.2

10. 20.Double GC:GC Mismatch in dsDNA Enhances Local Dynamics Retaining the DNA Footprint: A High-Resolution NMR Study. Ghosh A, Kar RK, Krishnamoorthy J, Chatterjee S*, Bhunia A*. ChemMedChem. 2014 Sep;9(9):2059-64. doi: 10.1002/cmdc.201402238. Epub 2014 Jul 30 IF= 3.0

 

11. Indolicidin Targets Duplex DNA: Structural and Mechanistic Insight through a Combination of Spectroscopy and Microscopy Anirban Ghosh, Rajiv Kumar Kar, Jagannath Jana, Abhijit Saha, Batakrishna Jana, Janarthanan Krishnamoorthy, Dinesh Kumar, Surajit Ghosh*, Dr. Subhrangsu Chatterjee* and Dr. Anirban Bhunia* ChemMedChem. Volume 9, Issue 9, pages 2052–2058, September 2014IF= 3.0

 

12.Novel gain-of-function for transcription factor FoxP3 as co-transcription factor of STAT3 in Treg cells (2013) Dewan Md Sakib Hossain1, Suchismita Mohanty1, Abir K. Panda1, Pushpak Bhattacharjee1, Sankar Bhattacharyya1, Argha Manna1, Shuvomoy Banerjee1, Arghya Adhikary1, Rajiv K. Kar2, Tanya Das1 Subhrangsu Chatterjee2and Gaurisankar Sa1*. Immunity 39, 1057– 1069, December 12, 2013IF= 19.7

 

13.Applications of saturation transfer difference NMR in biological systems. Bhunia A, Bhattacharjya S, Chatterjee SDrug Discovery Today 2011 Volume 17, Numbers 9/10, page 505-513. IF= 6.55


Patent:

Cancer Chemotherapeutic Agent/Formulation, Manufacture and Use Thereof.

US patent Number: US9682926B2 (Granted)

 

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Recognition:

    Teaching:

    Present:

    Image Name Designation Department Campus Contact number Email
    profile image Ananya Roy JRF Biophysics Centenary 25693340
    profile image Anindya Dutta SRF Biophysics Centenary 25693340
    profile image Meghomukta Mukherjee JRF Biophysics Centenary 25693340 megh19
    profile image Mitali Manna JRF Biophysics Centenary 25693218
    profile image Nilanjan Banerjee SRF Biophysics Centenary 25693340 nbanerjee
    profile image Pallabi Sengupta JRF Biophysics Centenary 25693340 pallabi_csir.bpc
    profile image Suman Panda JRF Biophysics Centenary 25693340

    Former:

    1. Dr. Jagannath Jana  (Postdoctoral Fellow at Institute of Curie, Paris, France)

    2. Ms. Jyotsna Bhat (Thesis Submitted)

    3. Ms. Soma Mandal (DBT Research Assistant at SINP, Kolkata) ( Thesis Submitted)

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