Anup Kumar Misra

Anup Kumar Misra
Professor

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Previous appointments:

Professor, Department of Chemical Sciences, Bose Institute, Kolkata, India January 2016-Till date

Associate Professor, Division of Molecular Medicine, Bose Institute, Kolkata, India August 2010-December 2015

Assistant Professor, Division of Molecular Medicine, Bose Institute, Kolkata, India October 2008-July 2010

Scientist-C and E1, Medicinal and Process Chemistry Division, Central Drug Research Institute (C.S.I.R), Lucknow, India Sept. 2001-Sept. 2008

Senior Research Scientist, Chembiotek Research Pvt. Ltd. (TCG Lifesciences), Kolkata 2000-2001

Postdoctoral Research Fellow with Prof. Ole Hindsgaul and Prof. Minoru Fukuda, The Burnham Institute, La Jolla, USA 1998-2000

Postdoctoral Research Fellow with Prof. R. A. Field and Prof. S. W. Homans, University of St. Andrews, Scotland 1997-1998

Research interests:

Main research interest is to develop synthetic strategies for the synthesis of complex saccharide molecules of biological interest and their glycoconjugates to use them in the immunochemical studies towards the preparation of anti-microbial vaccine candidates.

The group is also engaged in the design and synthesis of medicinally important small molecules (e.g. anti-filarial, anticancer agents, antioxidantsis and enzyme inhibitors etc ) and their bioevaluation in a collaborative program

Contact:

Address: Chemical Sciences
Unified Academic Campus
Bose Institute
EN-80, Sector V
Bidhan Nagar
Kolkata - 700 091, India
E-Mail: anup[at]jcbose.ac.in
Phone: +91-33-25693266

Research:

1. Design and Syntheses of molecules for their biological evaluation

 (a) In continuation of our ongoing program on the synthesis and bioevaluation of natural products and their analogs a series of glycosyl trizolyl terpenoid derivatives were synthesized and evaluated for their anticancer activities against different cancer cells. Several compounds were found anticancer agents and their detailed biological studies are under progress.

(b) A series of analogs of Resveratrol, a well known anticancer agent were prepared and their evaluation as anti filarial agents and anticancer agents are under progress.

(c) A series of aryl bisindolylmethane derivatives were prepared using an eco-friendly condition in water and their evaluation as CA-ATPase modulator and anticancer agent is ongoing.

(d) Cell wall glycoconjugates corresponding to the Meningitidis type X and A (MenX and A) have been prepared by the synthesis of the respective cell wall polysaccharide fragments by chemical glycosylations and then coupled with tetanus toxoid protein. The glycol-protein conjugates were evaluated for their antigenic functions and found promising lead for the development of the meningococcal vaccines.

(e) A collaborative program has been initiated under DST twinning project for the isolation, characterization and bioevaluation of natural products and preparation of their synthetic analogs.

 2. Studies on synthetic organic chemistry particularly carbohydrate chemistry:

 A large number of complex oligosaccharides corresponding to the antigenic cell wall polysaccharides of pathogenic bacteria have been synthesized using several novel techniques. These synthetic oligosaccharides act as important precursors for the preparation of glycoconjugates by attaching them with appropriate proteins under reductive amination methodologies. Synthetic glycoconjugates will be used to raise antibodies against them for their application in the development of diagnostic markers as well as antimicrobial agents.

A number of synthesized oligosaccharides were subjected to Molecular dynamics simulation studies to get the conformational structural insights of the compounds for designing glycomimetics corresponding to these molecules.

Publications:

 

161.     Si A & Misra AK. Facile synthesis of a rare sugar intermediate: D-gulopyranosyl cyanide. Trends Carbohydr. Res., 9, 63 - 66 (2017).

 

160.     Bhaumik I & Misra AK. Convergent  synthesis of the tetrasaccharide repeating unit of the O-polysaccharide of Salmonella enterica O41. Chemistry Select, 2, 3065 - 3067 (2017).

 

159.     Ghosh T, Si A & Misra AK. Facile transformation of nitriles into thioamides: Application to C-Glycosyl Nitrile Derivatives. Chemistry Select, 2, 1366 - 1369 (2017).

 

158.     Bhaumik I & Misra AK. Concise synthesis of a pentasaccharide repeating unit corresponding to the O-Antigen of Salmonella enterica O51. Chemistry Select, 2, 937 - 939 (2017).

 

157.     Roy C, Alam M, Mandal S, Haldar PK, Bhattacharya S, Mukherjee T, Roy R, Rameez MJ, Misra AK, Chakraborty R, Nanda AK, Mukhopadhyay SK & Ghosh W. Global association between thermophilicity and vancomycin susceptibility in bacteria. Front. Microbiol, 7:412 (2016). doi: 10.3389/fmicb.2016.00412.

 

156.     Chakraborty S, Ghosh S, Banerjee B, Santra A, Adhikary A, Misra AK & Sen PC. Phemindole, a synthetic di-indole derivative maneuvers the store operated calcium entry (SOCE) to induce potent anti-carcinogenic activity in human triple negative breast cancer cells. Frontiers in Pharmacology, 7, 114/1 - 114/21 (2016).

 

155.     Chakraborty S, Ghosh S, Banerjee B, Santra A, Bhat J, Adhikary A, Chatterjee S, Misra AK & Sen PC. Mephebrindole, a synthetic indole analog coordinates the crosstalk between p38MAPK and eIF2α/ATF4/CHOP signalling pathways for induction of apoptosis in human breast carcinoma cells. Apoptosis, 21, 1106 - 1124 (2016).

 

154.     Bhaumik I & Misra AK. Expedient synthesis of the pentasaccharide repeatingunit of the O-antigen of Escherichia coli O86and its conformational analysis. Glycoconj J, 33, 887 - 896 (2016).

 

153.     Si A & Misra AK. Synthesis of a pentasaccharide repeating unit corresponding to the cell wall O-antigen of Escherichia coli O59 using iterative glycosylations in one pot. Tetrahedron, 72, 4435 - 4444 (2016).

 

152.     Gucchait A, Jana M, Jana K & Misra AK. Preparation of glycosyl thiourea derivatives from glycosyl azides using sulfamic acid and sodium iodide in one-pot. Carbohydrate Research, 434, 107 - 112 (2016).

 

151.     Roy P, Dhara D, Parida PK, Kar RK, Bhunia A, Jana K, Sinha Babu SP & Misra AK. C-Cinnamoyl glycosides as a new class of anti-filarial agents. Eur. J. Med. Chem, 114, 308 - 317 (2016).

 

150.     Mukherjee N, Parida PK, Santra A, Ghosh T, Dutta A, Jana K, Misra AK & Sinha Babu SP. Oxidative stress plays major role in mediating apoptosis in filarial nematode Setaria cervi in the presence of trans-stilbene derivatives. Free Rad. Biol. Med., 93, 130 - 144 (2016).

 

149.     Rahkila J, Misra AK, Guazzelli L & Leino R. Glycosylation of phenolic acceptors using benzoylated glycosyl trichloroacetimidate donors. Carbohydrate Chemistry: Proven Synthetic Methods, 3, 97 - 105 (2015).

 

148.     Misra AK, Bokor É, Kun S, Bolyog-Nagy E, Kathó Á, Joó F, Somsák L. Chemoselective hydration of glycosyl cyanides to C-glycosyl formamides using ruthenium complexes in aqueous media. Tetrahedron Letters, 56, 5995 - 5998 (2015).

 

147.     Si A & Misra AK. Expedient synthesis of the pentasaccharide repeating unit of the polysaccharide O-antigen of Escherichia coli O11. Chemistry Open, 5, 47 - 50 (2015).

 

146.     Ghosh T & Misra AK. Facile synthesis of the heptasaccharide repeating unit of the cell wall O-polysaccharide of enterotoxigenic Escherichia coli O139. Chemistry Open, 5, 43 - 46 (2015).

 

145.     Santra A, Ghosh T & Misra AK. Synthesis of di- and trisaccharides related to the O-polysaccharide of Shigella dysenteriae type 8. J. Carbohydr. Chem., 34, 501 - 513 (2015).

 

144.     Dhara D & Misra AK. Convergent Synthesis of Oligosaccharide Fragments Corresponding to the Cell Wall O-Polysaccharide of Salmonella enterica O53. Chemistry Open, 4, 768 - 773 (2015).

 

143.     Jana M & Misra AK. Synthesis of trisaccharide and a tetrasaccharide repeating unit corresponding to the O-antigen of Shiga toxin producing Escherichia coli O177. Tetrahedron, 71, 3960 - 3965 (2015).

 

142.     Harale KR, Dumare NB, Singh D, Misra AK & Chhikara MK. Synthesis of a tetrasaccharide and its glycoconjugate corresponding to the capsular polysaccharide of Neisseria meningitidis serogroup X and its immunochemical studies. RSC: Adv., 5, 41332 - 41340 (2015).

 

141.     Si A & Misra AK. Efficient synthesis of the pentasaccharide repeating unit of the O-antigenic polysaccharide of Escherichia coli O166 strain. Synthesis, 47, 83 - 88 (2015).

 

140.     Bhaumik I & Misra AK. Expedient synthesis of a pentasaccharide related to the O-specific polysaccharide of Escherichia coli O117:K98:H4 strain. RSC: Adv., 4, 61589 - 61595 (2014).

 

139.     Ghosh T, Kar RK, Bhunia & Misra AK. Synthesis of the pentasaccharide repeating unit of the O-antigen of Escherichia coli O175 using one-pot glycosylations and its conformational analysis. Tetrahedron, 70, 9262 - 9267 (2014).

 

138.     Bhaumik I, Ghosh T & Misra AK. Efficient synthesis of the tetrasaccharide repeating unit of the O-antigen of Escherichia coli O174 strain. Carbohydr. Res., 399, 21 - 25 (2014).

 

137.     Jana M, Kar RK, Bhunia & Misra AK. Synthesis of the tetrasaccharide repeating unit of the O-antigen of Escherichia coli O69 strain and its conformational analysis. RSC Adv., 4, 37079 - 37084 (2014).

 

136.     Mandal PK, Dhara D & Misra AK. Concise synthesis of the repeating units of the cell wall lipopolysaccharide of Azospirillum brasilense SR80. Synthesis, 1947 - 1953 (2014).

 

135.     Parida PK, Sau A, Ghosh T, Jana K, Biswas K, Raha S & Misra AK. Synthesis and evaluation of triazole linked glycosylated 18b-glycyrrhetinic acid derivatives as anticancer agents. Bioorganic Medicinal Chem. Letters, 24, 3865 - 68 (2014).

 

134.     Dhara D, Kar RK, Bhunia & Misra AK. Convergent synthesis and conformational analysis of the hexasaccharide repeating unit of the O-antigen of Shigella flexneri serotype 1d. European  Journal of Organic Chemistry, 4577 - 4584 (2014).

 

133.     Santra A, Si A, Kar RK, Bhunia A & Misra AK. Linear synthesis and conformational analysis of the pentasaccharide repeating unit of the cell wall O-antigen of Escherichia coli O13. Carbohydrate Research, 391, 9 - 15 (2014).

 

132.     Jana M, Sau A & Misra AK. Synthesis of a pentasaccharide repeating unit of the O-antigen of enteroadherent Escherichia coli O154 strain. Tetrahedron: Asymm., 25, 632 - 636 (2014).

131.     Dhara D, Mandal PK & Misra AK. Convergent synthesis of a pentasaccharide repeating unit corresponding to the cell wall O-antigen of Salmonella enteric O44. Tetrahedron: Asymmetry, 25, 263 - 267 (2014).

 

130.     Mandal PK, Dhara D & Misra AK. Convergent synthesis of a tetrasaccharide repeating unit of the O-specific polysaccharide from the cell wall lipopolysaccharide of Azospirillum brasilense strain Sp7. Beilstein J. Org. Chem., 10, 293 - 299 (2014).

 

129.     Ghosh T, Santra A & Misra AK. Convergent synthesis of a hexasaccharide corresponding to the cell wall O-antigen of Escherichia coli O41. RSC Adv., 4, 54 - 60 (2014).

 

128.     Sau A, Dhara D & Misra AK. Concise synthesis of a pentasaccharide repeating unit corresponding to the O-antigen of Escherichia coli O102. Tetrahedron: Asymmetry, 24, 942 - 946  (2013).

 

127.     Jana M & Misra AK. Concise synthesis of the tetrasaccharide repeating unit of the O-antigen of Escherichia coli O16. Beilstein J. Org. Chem., 9, 1757 - 1762 (2013).

 

126.     Dhara D & Misra AK. Expedient synthesis of a tetrasaccharide and a pentasaccharide corresponding to the cell wall O-antigen of Escherichia coli O77 and Escherichia coli O17. Tetrahedron: Asymmetry, 24, 1488 - 1494 (2013).

 

125.     Santra A & Misra AK. Synthesis of a common tetrasaccharide repeating   of the O-antigen of enteroinvasive Escherichia coli O143 and Shigella boydii type 8. Current Organic Synthesis, 10, 178 - 182 (2013).

 

124.     Ghosh T, Santra A & Misra AK. Facile synthesis of a pentasaccharide repeating unit corresponding to the common O-antigen of Salmonella enterica O57 and E. coli O51. Tetrahedron: Asymmetry, 24, 606 - 611 (2013).

 

123.     Guchhait G & Misra AK. Short synthesis of the common trisaccharide core of kankanose and kankanoside isolated from Cistanche tubulosa. Beilstein J. Org. Chem., 9, 705 - 709 (2013).

 

122.     Jana M & Misra AK. Stereoselective synthesis of b-glycosyl thiols and their synthetic applications. J. Org. Chem., 78, 2680 - 86 (2013).

 

121.     Santra A, Guchhait G & Misra AK. Nitrosyl tetrafluoroborate catalyzed preparation of 2,3-unsaturated and 2-deoxy glycosides of hindered alcohols, thiols and sulfonamides. Synlett, 24 581 - 586 (2013).

 

120.     Ghosh T, Santra A & Misra AK. Appel reagent mediated transformation of glycosyl hemiacetal derivatives into thioglycosides and glycosyl thiols. Beilstein J. Org. Chem., 9, 974 - 982 (2013).

 

119.     Santra A, Ghosh T & Misra AK. Removal of benzylidene acetal and benzyl ether in carbohydrate derivatives using triethylsilane and Pd/C. Beilstein J. Org. Chem., 9, 74 - 78 (2013).

 

118.     Sau A & Misra AK. Convergent synthesis of the tetrasaccharide repeating unit of the cell wall lipopolysaccharide of Escherichia coli O40. Beilstein J. Org. Chem., 8, 2053 - 2059 (2012).

 

117.     Jana M & Misra AK. Significantly fast synthesis of glycosyl dithiocarbamate and trithiocarbonate derivatives under solvent-free condition. Synlett, 23, 2789 - 2794 (2012).

 

116.     Sau A, Santra A & Misra AK. Stereoselective glycosylations by nitrosyl tetrafluoroborate catalyzed activation of glycosyl trichloroacetimidate derivatives. Synlett, 23, 2341 - 2348 (2012).

 

115.     Ghosh T & Misra AK.             Facile synthesis of the pentasaccharide repeating unit of the cell wall O-antigen of Escherichia coli 19ab. Carbohydrate Research, 362, 8 - 12 (2012).

 

114.     Santra A, Ghosh T & Misra AK. Expedient synthesis of two structurally close tetrasaccharides corresponding to the O-antigens of Escherichia coli O127 and S. enterica O13. Tetrahedron: Asymmetry, 23, 1385 - 1392 (2012).

 

113.     Sau A & Misra AK. Reaction of glycal derivatives with alcohols in the presence of N-Bromosuccinimide (NBS) and diphenyldiselenide: Preparation of 2-deoxy-2-phenylselenyl glycosides. Carbohydrate Research, 361, 41 - 48 (2012).

 

112.     Sau A & Misra AK. Synthesis of the tetrasaccharide motif and its structural analog corresponding to the O-specific lipopolysaccharide of Escherichia coli O75. PLoS: One, 7, e37291 (2012).

 

111.     Santra A & Misra AK. Convergent synthesis of the pentasaccharide repeating unit of the O-antigenic polysaccharide of enterohaemorrhagic Escherichia coli O113. Glycoconjugate Journal, 29, 181 - 188 (2012).

 

110.     Sau A, Panchadhayee R, Ghosh D & Misra AK. Synthesis of a tetrasaccharide analog corresponding to the repeating unit of the O-polysaccharide of Salmonella enterica O59: Unexpected stereo outcome in glycosylation. Carbohydrate Research, 352, 18 - 22 (2012).

 

109.     Guchhait G & Misra AK. Convergent synthesis of the tetrasaccharide repeating unit corresponding to the O-antigen of the vero-toxin producing E. coli O176. Glycoconjugate Journal, 28, 519 - 524 (2011).

 

108.     Santra A & Misra AK. Convergent synthesis of the tetrasaccharide repeating unit of the O-antigen of Shigella boydii type 9. Beilstein J. Org. Chem., 7, 1182 - 1188 (2011).

 

107.     Panchadhayee R & Misra AK. Convergent synthesis of the pentasaccharide repeating unit of the O-antigen of Shigella boydii type 14. Tetrahedron: Asymmetry, 22, 1390 - 1394 (2011).

 

106.     Guchhait G & Misra AK. Efficient glycosylation of unprotected sugars using sulfamic acid: a mild eco-friendly catalyst. Catalysis Communications, 14, 52 - 57 (2011).

 

105.     Guchhait G & Misra AK. Environmentally benign synthesis of 2,3-unsaturated glycopyranosides in task-specific ionic liquid. Catalysis Letters, 141, 925 - 930 (2011).

 

104.     Sau A & Misra AK. Odorless eco-friendly synthesis of thio- and selenoglycosides in ionic liquid. Synlett, 1905 – 1911 (2011).

 

103.     Santra A & Misra AK. Synthesis of thioglycosides in room temperature ionic liquid. J. Carbohydr. Chem., 30, 85 - 93 (2011).

 

102.     Sau A & Misra AK. Environmentally benign preparation of benzylidene acetal of carbohydrate derivatives in PEG 600. J. Carbohydr. Chem., 30, 41 - 46 (2011).

 

101.     Santra A, Guchhait G & Misra AK. Efficient acylation and sulfation of carbohydrates using sulfamic acid, a mild, eco-friendly catalyst under organic solvent-free condition. Green Chemistry, 13, 1345 - 51 (2011).

100.     Guchhait G & Misra AK. Convergent synthesis of a common pentasaccharide corresponding to the O-antigen of Escherichia coli O168 and Shigella dysenteriae type 4. Glycoconjugate Journal, 28, 11 - 19 (2011).

 

99.       Santra A & Misra AK. Synthesis of tri- and penta-saccharide fragments corre-sponding to the O-abtigen of Shigella boydii type 6. Tetrahedron: Asymmetry, 21, 2612 - 2618 (2010).

 

98.       Ghosh S & Misra AK. Synthesis of the hexasacch-aride repeating unit corres-ponding to the cell wall lipopoly-saccharide of Azospirillum irakense KBC1. Tetrahedron: Asymmetry, 21, 2755 - 2761 (2010).

 

97.       Mukherjee C, Ghosh S, Nandi P, Sen PC & Misra AK. Efficient synthesis of (6-deoxy-glycopyranosid-6-yl)-sulfone derivatives and their effect on Ca2+-ATPase. Eur. J. Med. Chem., 45, 6012 - 6019 (2010).

 

96.       Panchadhayee R & Misra AK. Convenient synthesis of  penta- and hexasaccharide fragments corresponding to the O-antigen of Escherichia coli O150. Tetrahedron: Asymmetry, 21, 2142 - 2152 (2010).

 

95.       Panchadhayee R & Misra AK. Convergent synthesis of a common pentasaccharide repeating unit corresponding to the O-specific polysaccharide of Escheriachia coli O4: K3, O4:K6 and O4:K12. Tetrahedron: Asymmetry, 21, 859 - 863 (2010).

 

94.       Ghosh S & Misra AK. Synthesis of a hexasaccharide corresponding to Azospirillum lipoferum Sp59b lipopolysaccharide. Tetrahedron: Asymmetry, 21, 725 - 730 (2010).

 

93.       Panchadhayee R & Misra AK. Regioselective reductive ring-opening of benzylidene acetals using triethylsilane and I2. Synlett, 1193 - 1196 (2010).

 

92.       Singh S, Mandal PK, Singh N, Misra AK, Singh S, Chaturvedi V, Sinha S & Saxena AK. Substituted hydrazinecarbothioamide as potent antitubercular agents: Synthesis and quantitative structure–activity relationship (QSAR). Bioorg. Med. Chem. Lett., 20, 2597 - 2600 (2010).

 

91.       Panchadhayee R & Misra AK. Removal of anomeric allyl group using N-bromo succinimide (NBS): preparation of glycosyl hemiacetals. J. Carbohydr. Chem., 29, 76 - 83 (2010).

 

90.       Mandal PK & Misra AK. Concise Synthesis of the pentasaccharide O-antigen corresponding to the Shiga toxin producing Escherichia Coli O171. Bioorganic Chemistry, 38, 56 - 61 (2010).

 

89.       Guchhait G & Misra AK. Synthesis of the trisaccharide O-antigen of Rahnella aquatilis 1-95. J. Carbohydr. Chem., 29, 1 - 9 (2010).

 

88.       Ghosh S & Misra AK. Synthesis of a tetra-saccharide corresponding to the teichoic acid from the cell wall of Strepto-myces sp. VKM Ac-2275. Tetrahedron: Asymmetry, 20, 2688 - 93 (2009).

 

87.       Panchadhayee R & Misra AK. Synthesis of tri- and disaccharide fragments related to the O-antigen of enteropathogenic Escherichia coli O158. J. Carbohydr. Chem., 29, 39 - 50 (2010).

 

86.       Ghosh S & Misra AK. Concise synthesis of a hexasaccharide related to the adhesin receptor of Streptococcus oralis ATCC 55229. J. Carbohydr. Chem., 28, 447 - 462 (2009).

 

85.       Mukherjee C & Misra AK. Synthesis of (6,6¢)-C-linked pseudodisaccharides. J. Carbohydr. Chem., 28, 475 - 482 (2009).

 

84.       Guchhait G & Misra AK. Total synthesis of the heptasaccharide of the iron-binding exopoly-saccharide secreted by Klebsiela oxytoca BAS-10. Tetrahedron: Asymmetry, 20, 1791 - 1797 (2009).

 

83.       Pandey S, Ghosh S & Misra AK. Synthesis of a tri and tetra-saccharide present in the cell wall lipopolysaccharides of Azospirilum brasilense S17. Synthesis, 2584 - 2590 (2009).

 

82.       Mandal PK & Misra AK. Efficient synthesis of two sialylated tetrasaccharides found in goat milk. Synthesis, 1348 - 1354 (2009).

 

81.       Panchadhayee R & Misra AK. First synthesis of a pentasaccharide repeating unit of the O-antigenic polysaccharide from enterohemorrhagic E. coli O48:H21. Tetrahedron: Asymmetry, 20, 1550 - 1555 (2009).

 

80.       Mukherjee C & Misra AK. Total synthesis of a unique tetrasaccharide present in the Human Clotting Factor IX and mammalian Notch 1 receptor. Tetrahedron: Asymmetry, 20, 473 - 477 (2009).

 

79.       Mandal PK, Maiti GH & Misra AK. Facile synthesis of a tetrasaccharide corresponding to the capsular polysaccharide of Streptococcus pneumoniae type 15B. Arkivoc, (ii), 281 - 287 (2009).

 

78.       Panchadhayee R & Misra AK. Odorless regioselctive ring opening of epoxides with S-alkylisothio-uronium salts as masked thiols in water. Arkivoc, (ii) 298 - 307 (2009).

 

77.       Ghosh S, Misra AK, Bhatia G, Khan M & Khanna A. Syntheses and evaluation of glucosyl aryl thiosemi-carbazide and glucosyl thiosemicarbazone derivatives as antioxidant, anti-dyslipidemic agents. Bioorg. Med. Chem. Lett., 19, 386 - 389 (2009).

 

76.       Mukherjee C & Misra AK. Synthesis of a unique trisaccharide having an acetal linkage between openchain and cyclic sugar found in the cell wall of Proteus. Tetrahedron: Asymm., 19, 2746 - 51 (2008).

 

75.       Panchadhayee R & Misra AK. Efficient preparation of benzylidene acetal in carbohydrate derivatives. J. Carbohydr. Chem., 27, 148 - 155 (2008).

 

74.       Mandal PK & Misra AK. Concise synthesis of the pentasaccharide O-antigen of Escherichia coli O83 present in colinfant vaccine. Glycoconjugate J., 25, 713 - 722 (2008).

 

73.       Kumar R, Maulik PR & Misra AK. Concise chemical synthesis of a tetrasaccharide repeating unit of the O-antigen of Hafnia alvei 10457. Glycoconjugate J., 25, 511 - 519 (2008).

 

72.       Mukherjee C & Misra AK. Total synthesis of an antigenic heptasaccharide motif found in the cell-wall lipooligosaccharide of Mycobacterium gordonae strain 989. Glycoconjugate J., 25, 611 - 624  (2008).

 

71.       Tiwari P & Misra AK. Synthesis of oligosaccharide fragments corresponding to the exopolysaccharide released by Streptococcus macedonicus  Sc 136. Glycoconjugate J., 25, 85 - 99 (2008).

 

70.       Mukherjee C & Misra AK. First total synthesis of a pentasaccharide repeating unit of the O-antigen of Hafnia alvei PCM 1529. Glycoconjugate J., 25, 111 - 119  (2008).

 

69.       Kumar R, Maulik PR & Misra AK. Significantly rapid access to glycosyl triazole and tetrzoles from reducing sugars in one-pot. Glycoconjugate J., 25, 595 - 602 (2008).

 

68.       Mandal PK & Misra AK. Catalyst-free efficient synthesis of 3-thio-2-deoxysugar derivatives in water. J. Carbohydr. Chem., 27, 238 - 257 (2008).

 

67.       Panchadhayee R & Misra AK. Concise synthesis of a heptasaccharide antigen found in the cell-wall lipopolysaccharide of M. gordonae strain 990. Glycoconjugate J., 25, 817 - 826 (2008).

66.       Mandal PK & Misra AK. Efficient acetylation and preparation of Boc derivatives of carbohydrate, amines and phenols. Letters in Organic Chemistry, 5, 194 - 201 (2008).

 

65.       Ghosh S, Tiwari P, Pandey S, Misra AK, Chaturvedi V, Gaikwad A, Bhatnagar S & Sinha S. Synthesis and evaluation of antitubercular activity of glycosyl thio- and sulfonyl acetamide derivatives. Bioorg. Med. Chem. Lett., 18, 4002 - 4005 (2008).

 

64.       Mandal PK & Misra AK. Concise synthesis of two pentasaccharides corresponding to the a-chain oligosaccharides of N. gonorrhoeae and N. meningitides. Tetrahedron, 64, 8685 - 8691 (2008).

 

63.       Mukherjee C, Maiti GH & Misra AK. Regioselective ring opening of epoxides with thiols in water. Arkivoc, (xi) 46 - 55 (2008).

 

62.       Mandal PK & Misra AK. Synthesis of Oligosaccharides Corresponding to the Polysaccharides of Lactobacillus and Thermophilus Strains. Synthesis, 2660 - 2666 (2007).

 

61.       Agnihotri G, Mandal PK & Misra AK. Concise synthesis of two trisaccharide analogs related to the glycone constituent of Phanoside, a novel insulin releasing natural product. Tetrahedron, 63, 7240 - 45 (2007).

 

60.       Tiwari P & Misra AK. Synthesis of a pentasaccharide repeating unit of the extracellular polysaccharide produced by L. delbrueckii subsp. bulgaricus 291. J. Carbohydr. Chem., 26, 239 - 248 (2007).

 

59.       Kumar R, Maulik PR & Misra AK. Synthesis of glycosyl enaminones from glycosyl azides.

J. Carbohydr. Chem., 26, 83 - 90 (2007).

 

58.       Mukherjee C & Misra AK. Odorless preparation of thioglycosides and thio michael adducts of carbohydrate derivatives. J. Carbohydrate Chemistry, 26, 213 - 221 (2007).

 

57.       Mukherjee C & Misra AK. Glycosylation and pyranose-furanose isomerization of carbohydrates using HClO4-SiO2: Synthesis of oligosaccharides containing galactofuranose. Synthesis, 683 - 692 (2007).

 

56.       Mukherjee C & Misra AK. Aza-Michael addition of amines to activated alkenes catalyzed by Silica suppo-rted perchloric acid under a solvent-free condition. Letters in Organic Chemistry, 4, 54 - 59 (2007).

 

55.       Mandal PK & Misra AK. Mild and efficient hydrolysis of thioglycosides to glycosyl hemiacetals using N-iodosaccharin. Synlett, 1207 - 1210 (2007).

 

54.       Madhusudana KP, Kumar B, Kanojiya S, Agnihotri G & Misra AK. Tandem mass spectra of divalent metal ion adducts of glycosyl sulfides, sulfoxides and sulfones, distinction among stereoisomers. J. Mass Spectrometry, 41, 1322 – 1333 (2006).

 

53.       Agnihotri G & Misra AK. Synthesis of a di- and a trisaccharide related to the O-antigen of Escherichia coli O83: K24: H31. Carbohydrate Research, 341, 2420 - 2425 (2006).

 

52.       Tiwari P, Puri A, Chander, Bhatia G & Misra AK. Synthesis and antihyperlipidemic activity of novel glycosyl fructose derivatives. Bioorg. Med. Chem. Lett., 16, 6028 - 6033 (2006).

 

51.       Agnihotri G & Misra AK. Facile synthesis of pyruvate ketals of carbohydrates. Tetrahedron Letters, 47, 8493 - 97 (2006).

 

50.       Agnihotri G, Tiwari P & Misra AK. Unprecedented transforma-tion of thioglycosides to their corresponding 1-O-acetates in the presence of HClO4-SiO2. Journal of Carbohydrate Chemistry, 25, 491 - 498 (2006).

 

49.       Mandal PK & Misra AK. HClO4-SiO2 catalyzed multicomponent reactions for the synthesis of privileged heterocyclic structures. Letters in Organic Chemistry, 3, 848 - 853 (2006).

 

48.       Tiwari P & Misra AK. An Efficient Stereoselective Dihydroxylation of Glycals using a Bimetallic System, RuCl3/CeCl3/NaIO4. Journal of Organic Chemistry, 71, 2911 - 2913 (2006).

 

47.       Kumar R, Tiwari P, Maulik PR & Misra AK. HClO4-SiO2 catalyzed chemoselective synthesis of acylals from aldehydes under solvent-free conditions. Journal of Molecular Catalysis: A, 247, 27 - 30 (2006).

 

46.       Tiwari P & Misra AK. Acylation of carbohydrates over Al2O3: preparation of partially and fully acylated carbohydrate derivatives and acetylated glycosyl chlorides. Carbohydrate Research, 341, 339 - 350 (2006).

 

45.       Mukherjee C, Tiwari P & Misra AK. Synthesis of thio- and selenoglycosides by cleavage of dichalconides in the presence of zinc/zinc chloride and reaction with glycosyl bromides. Tetrahedron Letters, 47, 441 - 445 (2006).

 

44.       Tiwari P & Misra AK. Indium(I) iodide mediated efficient synthe-sis of selenoglycosides. Tetrahedron Letters, 47, 2345 - 48 (2006).

 

43.       Agnihotri G & Misra AK. Fast oxidation of thioglycosides to glycosyl sulfones using KMnO4/CuSO4·5H2O under neutral reaction conditions. Carbohydrate Research, 341, 275 - 280 (2006).

 

42.       Tiwari P & Misra AK. Selective removal of anomeric O-acetate groups in carbohydrates using HClO4-SiO2. Tetrahedron Letters, 47, 3573 - 76 (2006).

 

41.       Agnihotri G & Misra AK. Mild and efficient method for the cleavage of benzyli-dene acetals using HClO4–SiO2 and direct conversion of acetals to acetates. Tetrahedron Letters, 47, 3653 - 3658 (2006).

 

40.       Kumar R, Tiwari P, Maulik PR & Misra AK. A Generalized Procedure for the One-Pot Preparation of Glycosyl Azides and Thioglycosides Directly from Unprotected Reducing Sugars under Phase Transfer Conditions. European Journal of Organic Chemistry, 74 - 79 (2006).

 

39.       Agnihotri G & Misra AK. Fast and selective oxidation of thioglycosides to glycosyl sulfoxides using KF/m-CPBA. Tetrahedron Letters, 46, 8113 - 16 (2005).

 

38.       Tiwari P, Kumar R & Misra AK. Efficient acetylation of carbohydrates promoted by imidazole. Eur. J. Organic Chemistry, 4265 - 4270 (2005).

 

37.       Tiwari P, Agnihotri G & Misra AK. Modified one-pot protocol for the preparation of thioglycosides from unprotectted aldoses via S-glycosyl isothiouronium salts. Journal of Carbohydrate Chemistry, 24, 723 - 732 (2005).

 

36.       Kumar R, Tiwari P, Maulik PR & Misra AK. Comparative structural analysis of 5,6,7,9-tetra-O-acetyl-4,8-anhydro-1,3-dideoxy-d-glycero-l-gluco-nonulose and its 1-O-acetylated analog, 1,2,3,4,6-penta-O-acetyl-β-d-galactopyranose using X-ray crystallography. Carbohydrate Research, 340, 2335 - 2339 (2005).

 

35.       Madhusudan SK & Misra AK. Synthesis of a new type of glycosidic linkage: Acetal linked disaccharides and trisaccharides of acyclic and cyclic sugars. Eur. J.  Organic Chemistry, 3196 - 3205 (2005).

 

34.       Madhusudan SK & Misra AK. Facile exchange of glycosylS,S-acetals to their O,O-acetals and prepara-tion of glycofuranosides from acyclic glycosyl S,S-acetals under metal-free reaction conditions in the presence of 1,3-dibromo-5,5-dimethylhydantoin. Carbohydrate Research, 340, 497 - 502 (2005).

 

33.       Misra AK, Tiwari P & Agnihotri G. Ferrier rearrangement catalyzed by HClO4-SiO2: Synthesis of 2,3-unsaturated glycopyranosides. Synthesis, 260 - 266 (2005).

 

32.       Tiwari P, Agnihotri G & Misra AK. Synthesis of 2,3-unsatura-ted C-glycosides by HClO4-SiO2 catalyzed ferrier rearrangement of glycals. Carbohydrate Research, 340, 749 - 752 (2005).

 

31.       Misra AK, Tiwari P & Madhusudan SK. HClO4-SiO2 catalyzed per-O-acetylation of carbohydrates. Carbohydrate Research, 340, 325 - 329 (2005).

 

30.       Madhusudan SK, Agnihotri G, Negi DS & Misra AK. Direct one-pot conversion of acylated carbohydrates into their alkylated deriva-tives under heterogeneous reaction conditions using solid NaOH and a phase transfer catalyst. Carbohydrate Research, 340, 1373 - 1377 (2005).

 

29.       Madhusudana KP, Kumar B, Tiwari P, Madhusudan SK & Misra AK. Effect of metal cationization on the tandem mass spectra of glycosyl dithioacetals. Journal of Mass Spectrometry, 40, 25 - 35 (2005).

 

28.       Agnihotri G, Tiwari P & Misra AK. One-pot synthesis of per-O-acetylated thioglycosides from unprotected reducing sugars. Carbohydrate Research, 340, 1393 - 1396 (2005).

 

27.       Madhusudana KP, Tiwari P, Madhusudan SK & Misra AK. Tandem mass spectra of transition-metal ion adducts of glycosyl dithioacetals; distinction among stereoisomers. Rapid Commun. Mass Spectrometry, 19, 470 - 476 (2005).

 

26.       Misra AK & Agnihotri G. Chloramine–T mediated chemoselective hydrolysis of thioglycosides into glycosyl hemiacetals under neutral condition. Carbohydrate Research, 339, 885 - 890 (2004).

 

25.       Misra AK & Agnihotri G. Preparation of polyhydroxyalkyl- and C-glycosylfuran derivatives from free sugars catalyzed by cerium(III) chloride in aqueous solution: an improvement of the Garcia Gonzalez reaction. Carbohydrate Research, 339, 1381 - 1387 (2004).

 

24.       Misra AK, Agnihotri G, Madhusudan SK & Tiwari P. Practical synthesis of sulfated analogs of lactosamine and sialylated lactosamine derivatives. J. Carbohydrate Chemistry, 23, 191 - 199 (2004).

 

23.       Misra AK, Agnihotri G & Madhusudan SK. Microwave induced eco-friendly solvent-free Biginelli reaction catalyzed by calcium chloride. Ind. J. Chem., 43B, 2018 - 20 (2004).

 

22.       Misra AK & Agnihotri G. Nitric acid mediated oxidative transformation of thiols to disulfides. Synthetic Communications, 34, 1079 - 85 (2004).

 

21.       Sengupta P, Misra AK, Suzuki M, Fukuda M & Hindsgaul O.             Chemoenzymatic Synthesis Of Sialylated Oligosaccharides For Their Evaluation In A Polysialyltransferase Assay. Tetrahedron Lett., 44, 6037 - 6042 (2003).

 

20.       Akama TO, Misra AK, Hindsgaul O & Fukuda MN. Enzymatic synthesis in vitro of the Disulfated Disaccharide unit of Corneal Keratan Sulfate. J. Biol. Chem., 277, 42505 - 42513 (2002).

 

19.       Gastinel LN, Bignon C, Misra AK, Hindsgaul O, Shaper JH & Joziasse D. Bovine a 1, 3-galactosyl-transferase catalytic domain structure and its relationship with ABO histo-blood group andglycosphingolipid glycosyltransferases. EMBO J., 20, 638 - 649 (2001).

 

18.       Hiraoka N, Misra AK, Belot F, Hindsgaul O & Fukuda M. Molecular cloning and expression of two distinct human N-acetylgalacto-samine 4-O-sulfotrans-ferases that transfer sulfate to GalNAcb1-4GlcNAcb1-R in N- & O-glycans. Glycobiology, 11, 495 - 504 (2001).

 

17.       Misra AK, Fukuda M & Hindsgaul O. Efficient synthesis of lactosaminylated Core-2 O-Glycans. Bioorg. Med. Chem. Lett., 11, 2667 - 2669 (2001).

 

16.       Misra AK, Ujita M, Fukuda M & Hindsgaul O. Synthesis and enzymatic evaluation of mucin type core-4 O-Glycan. Carbohydr. Lett., 4, 71 - 76 (2001).

 

15.       Suzuki A, Hiraoka N, Angata K, Misra AK, McAuliffe J, Hindsgaul O & Fukuda M. Molecular cloning and expression of a novel human b-Gal-3-O-sulfotransferase that acts preferentially on N-acetyllactosamine in N- and O-glycans. J. Biol. Chemistry, 276, 24388 - 24395 (2001).

 

14.       Homiester JW, Thall A, Petrynaik B, Maly P, Rogers C, Smith P, Kelly R, Gersten K, Cheng G, Marks R, Misra AK, Hindsgaul O, Adrian UH von & Lowe JB. The a (1,3) fucosyltransferaces Fuc- TIV and Fuc-TVII co-dominantly control selectin ligand activities on leukocytes and high endothelial venules. Immunity, 15, 115 - 126 (2001).

 

13.       Ujita M, Misra AK, McAuliffe J, Hindsgaul O & Fukuda M. Poly-N-acetyllactosamine extention in N-glycans and core 2- and core 4- branch-ed O-glycans is differenti-ally controlled by i-exten-tion enzyme and different members of the b 1, 4-galactosyltransferase gene. J. Biol. Chem., 275(21), 15868 - 15875 (2000).

 

12.       Misra AK, Ding Y, Lowe JB & Hindsgaul O. A concise synthesis of the 6-O and 6′-O-sulfated analogues of the sialyl Lewis X tetrasaccharide. Bioorg. Med. Chem. Lett., 10 (14) 1505 - 1509 (2000).

 

11.       Nakayama J, Yeh J-C, Misra AK, Ito S, Katsuyama T & Fukuda M. Expression cloning of a human a1, 4-N-acetygluco-saminyl-transferase that forms GlcNAc a®4Galb ®R, a glycan specifically expressed in the gastric gland mucous cell-type mucin. Proc. Natl. Acad. Sci. (PNAS) U.S.A., 6, 8991 - 8996 (1999).

 

10.       Misra AK, Brown JM, Homans SW & Field RA. Synthesis of 13C-labelled methyl a-D-mannopyranosyl-(1®2)-a-D-mannopyrano-side from [U-13C]-D-Glucose. Carbohydr. Lett., View More

Recognition:

  • Visiting scientist to University of Debrecen, Hungary under INSA-HAS bilateral exchange program (April-June 2015), 2015
  • Dr. H.C. Srivastava young scientist award from Association of Carbohydrate Chemists and Technologists (India), 2014
  • Visiting scientist to Abo Akademy University, Turku, Finland (Aug-Oct. 2013) under DBT, India-Academy of Finland exchange program, 2013
  • Visiting scientist to University of Konstanz, Germany under INSA-DFG bilateral exchange program (March-May 2009), 2009
  • DST Ramanna Research Fellowship, 2007
  • CSIR Young Scientist Award in Chemical Sciences, 2005

Teaching:

PhD Course work coordinator: Structure elucidation and synthetic studies of bio-active medicinally important molecules.

Integrated MSc course: classes taken in chemistry biology course.

Students:

Image Name Designation Department Campus Contact number Email
profile image Abhijit Rana Junior Research Fellow Division of Molecular Medicine Centenary ranaabhijit70@gmail.com
profile image Aniket Majhi Junior Research Fellow Chemical Sciences Unified majhianiket9@gmail.com
profile image Saikat Dogra Junior Research Fellow Chemical Sciences Unified saikatdogra56@gmail.com
profile image Samim Sahaji Junior Research Fellow Division of Molecular Medicine Centenary samim.sahaji98@gmail.com

Former:

Former Group Members:

    Dr. Geetanjali Agnihotri

    Dr. Pallavi Tiwari

    Dr. Rishi Kumar

    Dr. Soni Kamlesh Madhusudan

    Dr. Chinmoy Mukherjee

    Dr. Pintu Kumar Mandal

    Dr. Rajib Panchadhayee

    Dr. Samir Ghosh

    Dr. Goutam Guchhait

    Dr. Abhishek Santra

    Dr. Abhijit Sau

    Dr. Manas Jana

    Dr. Tamashree Ghosh

    Dr. Debashis Dhara

    Dr. Kobirul Islam

    Dr. Utsab Debnath

    Dr. Anshupriya Si

    Dr. Ishani Bhaumik

    Dr. Ananya Dutta

   Dr. Arin Gucchait

    Dr. Tapashi Manna

   Dr. Pradip Shit

                                                                    Monalisa Kundu


Current Group Members:


Mr. Abhijit Rana

Mr. Samim Sahaji

CSIR-SRF

MANF-SRF

ranaabhijit70@gmail.com

samim.sahaji98@gmail.com


Mr. Satyajit Halder
CSIR-SRF
satyajithalder.dna@gmail.com


Group News:

For Junior Research Fellow positions Interested candidates having M.Sc. in Organic Chemistry may directly write to me (E-mail: akmisra69@gmail.com/anup@jcbose.ac.in). The candidate should have CSIR-JRF or UGC-JRF fellowship.