PhD: Department of Biochemistry, University of Calcutta, 2008
1. Max Planck Postdoctoral Fellow at Max Planck Institute for Terrestrial Microbiology, Marburg, Germany (2008-2012).
2. Research Associate at Department of Biochemistry, University of Calcutta (2012-2013).
3. DST-Ramanujan Fellow at Department of Biochemistry, Bose Institute (2014-2016).
1. Microbial (Archaea and Bacteria) stress response
2. Microbial genomics
3. Plant-microbe interaction
Department of Biochemistry
P-1/12 C.I.T. Scheme VII-M
Kolkata - 700054, India
Archaeal stress response:
Study of archaea, the third domain of life, can provide interesting insights into the evolutionary history of different cellular machineries and mechanisms across all life forms. One such mechanism of our concern is that of protein translocation across biological membranes in archaea. Our present focus is on the structural and functional analyses of molecules that are central to the archaeal secretion process under different limiting conditions. Since archaea can sustain such extreme limiting conditions, withstanding different kinds of stresses, we also aim to get a thorough idea about the effect of different types of stressors on archaeal cells at the transcriptomic and proteomic level. We want to study the fate of stress-related proteins under conditions of stress, which includes identification, characterization, and analysis of the mode of regulation of stress-related proteins and their targets. Therefore, the current research in our lab is concerned with understanding the effect of heat stress on archaea in regard with different molecular chaperones. In addition, our recent venture is to study the components of archaeal defense mechanism, that is, the CRISPR-Cas system and their mode of action in conferring resistance to biotic stress, such as foreign genetic elements.
Structural and Functional Genomics of Microbes:
Another area of interest of our lab is to understand the diversity, distribution, and interaction of microbes with the environment. Our model system of study, the Sundarbans are the largest single stretch of the deltaic halophytic mangrove ecosystem in the world and has been recognized as a world heritage site by UNESCO. Till date, only little is known about the microbial diversity, distribution, and function within this mangrove sediment. Hence, our group is interested in understanding the microbial diversity, with special emphasis on the archaea of this ecologically important region. In parallel to this, our group is also involved in studying plant-microbe interactions at the genomic and functional levels.
Bhattacharyya, A, Haldar, A, Bhattacharyya, M, Ghosh, A. (2019) Anthropogenic influence shapes the distribution of antibiotic resistant bacteria (ARB) in the sediment of Sundarban estuary in India. Sci Total Environ. 647: 1626-1639 doi: 10.1016/j.scitotenv.2018.08.038
Roy, M, Gupta, S, Patranabis, S, Ghosh, A. (2018) The oligomeric plasticity of Hsp20 of Sulfolobus acidocaldarius protects environment-induced protein aggregation and membrane destabilization. BBA-Biomembranes 1860(12): 2549-2565.
Roy, D, Pramanik, A, Banerjee, S, Ghosh, A, Chattopadhyay, D, Bhattacharyya, M. (2018) Spatio-temporal variability and source identification for metal contamination in the river sediment of Indian Sundarbans, a world heritage site. Environmental Science and Pollution Research 25(31):31326-31345. (DOI:10.1007/s11356-018-3092-x)
Mallick, I., Bhattacharyya, C., Mukherji, S., Dey, D., Sarkar, S.C., Mukhopadhyay, U.K., Ghosh, A. (2018) Effective rhizoinoculation and biofilm formation by arsenic immobilizing halophilic plant growth promoting bacteria (PGPB) isolated from mangrove rhizosphere: A step towards arsenic rhizoremediation. Sci Total Environ. 610-611:1239-1250.
Dutta, P., Mallick, I., Ghosh, A., and Basu, M. (2018) Study of Some Predominant Arsenic Resistance Bacteria from Soil Samples of Industrial Zones of West Bengal, India. Utilization and Management of Bioresources, by Springer Publisher Inc., January, pp: 195-208 (ISBN: 978-981-10-5349-8).
Mahato, M., Mukherji, S., Van Hecke, K., Harms, K., Ghosh, A., Nayek, H.P. (2017) Mononuclear homoleptic organotin(IV) dithiocarbamates: Syntheses, structures and antimicrobial activities. Journal of Organometallic Chemistry, 853:27-34. (https://doi.org/10.1016/j.jorganchem.2017.10.027)
Vinayak, R., Dey, D., Ghosh, D., Chattopadhyay, D., Ghosh, A., Nayek, H.P. (2017) Schiff Base Supported Mononuclear Organotin(IV) Complexes: Syntheses, Structures and Fluorescence Cell Imaging. Applied Organometallic Chemistry (doi: 10.1002/aoc.4122).
Bhattacharyya, C., Bakshi, U., Mallick, I., Mukherji, S., Bera, B., and Ghosh, A. (2017) Genome-guided insights into the plant growth promotion capabilities of the physiologically versatile Bacillus aryabhattai strain AB211. Frontiers in Microbiology 8:411 (doi: 10.3389/fmicb.2017.00411)
Mahanty, T., Bhattacharjee, S., Goswami, M., Bhattacharyya, P., Das, B., Ghosh, A., and Tribedi, P. (2016) Biofertilizers: a potential approach for sustainable agriculture development. Environ Sci Pol Res Int (doi: 10.1007/s11356-016-8104-0)
Basak, P., Pramanik, A., Sengupta, S., Nag, S., Bhattacharyya, A., Roy, D., Pattanayak, R., Ghosh, A., Chattopadhyay, D., and Bhattacharyya, M. (2016) Bacterial diversity assessment of pristine mangrove microbial community from Dhulibhashani, Sundarbans using 16S rRNA gene tag sequencing. Genomics Data 7:76-78.
Chaudhury, P., Neiner, T., D'Imprima, E., Banerjee, A., Reindl, S., Ghosh, A., Arvai, A.S., Mills, D.J., van der Does, C., Tainer, J.A., Vonck, J., and Albers S.V. (2016) The nucleotide-dependent interaction of FlaH and FlaI is essential for assembly and function of the archaellum motor. Mol Microbiol 99: 674-685.
Saha, S., Jana, S., Gupta, S., Ghosh, A., and Nayek, H.P. (2016) Syntheses, structures and biological activities of square planar Ni(II), Cu(II) complexes. Polyhedron 107: 183-189.
Basak, P., Majumder, N.S., Nag, S., Bhattacharyya, A., Roy, D., Chakraborty, A., SenGupta, S., Roy, A., Mukherjee, A., Pattanayak, R., Ghosh, A., Chattopadhyay, D., Bhattacharyya, M. (2015) Spatiotemporal Analysis of Bacterial Diversity in Sediments of Sundarbans Using Parallel 16S rRNA Gene Tag Sequencing. Microb Ecol 69: 500-511.
Bera, A., Ghosh, A., Mukhopadhyay, A., Chattopadhyay, D., and Chakrabarti, K. (2015) Improvement of degummed ramie fiber properties upon treatment with cellulase secreting immobilized A. larrymoorei A1. Bioproc Biosyst Eng 38: 341-351.
Bhattacharyya, A., Majumder, N.S., Basak, P., Mukherji, S., Roy, D., Nag, S., Haldar, A., Chattopadhyay, D., Mitra, S., Bhattacharyya, M., et al. (2015) Diversity and Distribution of Archaea in the Mangrove Sediment of Sundarbans. Archaea 968582.
Chakraborty, A., Bera, A., Mukherjee, A., Basak, P., Khan, I., Mondal, A., Roy, A., Bhattacharyya, A., SenGupta, S., Roy, D., Nag, S., Ghosh, A., Chattopadhyay, D., Bhattacharyya, M. (2015) Changing bacterial profile of Sundarbans, the world heritage mangrove: Impact of anthropogenic interventions. World J Microb Biotechnol 31: 593-610.
Mahato, M., Dey, D., Pal, S., Saha, S., Ghosh, A., Harms, K., and Nayek, H.P. (2015) Syntheses, structures, optical properties and biological activities of bimetallic complexes. RSC Advances 4: 64725-64730.
Sengupta, S., Pramanik, A., Ghosh, A., and Bhattacharyya, M. (2015) Antimicrobial activities of actinomycetes isolated from unexplored regions of Sundarbans mangrove ecosystem. BMC Microbiol 15: 170.
Wagner, M., Wagner, A., Ma, X., Kort, J.C., Ghosh, A., Rauch, B., Siebers, B., and Albers, S.V. (2014) Investigation of the malE promoter and MalR, a positive regulator of the maltose regulon, for an improved expression system in Sulfolobus acidocaldarius. Appl Env Microbiol 80: 1072-1081.
Reindl, S. *, Ghosh, A. *, Williams, G.J. *, Lassak, K., Neiner, T., Henche, A.L., Albers, S.V., and Tainer, J.A. (2013) Insights into FlaI functions in archaeal motor assembly and motility from structures, conformations, and genetics. Molecular Cell 49: 1069-1082. (* contributed equally)
Banerjee, A., Ghosh, A., Mills, D.J., Kahnt, J., Vonck, J., and Albers, S.V. (2012) FlaX, A Unique Component of the Crenarchaeal Archaellum, Forms Oligomeric Ring-shaped Structures and Interacts with the Motor ATPase FlaI. J Biol Chem 287: 43322-43330.
Henche, A.L., Ghosh, A., Yu, X., Jeske, T., Egelman, E., and Albers, S.V. (2012) Structure and function of the adhesive type IV pilus of Sulfolobus acidocaldarius. Environ Microbiol 14: 3188-3202.
Henche, A.L., Koerdt, A., Ghosh, A., and Albers, S.V. (2012) Influence of cell surface structures on crenarchaeal biofilm formation using a thermostable green fluorescent protein. Environ Microbiol 14: 779-793.
Lassak, K., Ghosh, A., and Albers, S.V. (2012) Diversity, assembly and regulation of archaeal type IV pili-like and non-type-IV pili-like surface structures. Res Microbiol 163: 630-644.
Lassak, K., Neiner, T., Ghosh, A., Klingl, A., Wirth, R., and Albers, S.V. (2012) Molecular analysis of the crenarchaeal flagellum. Mol Microbiol 83: 110-124.
Koerdt, A., Jachlewski, S., Ghosh, A., Wingender, J., Siebers, B., and Albers, S.V. (2012) Complementation of Sulfolobus solfataricus PBL2025 with an alpha-mannosidase: effects on surface attachment and biofilm formation. Extremophiles 16: 115-125.
Ray, R., Ghosh, A., Bera, A., Dutta, N., Chattopadhyay, D.J., and Chakrabarti, K. (2011) Analysis of differentially expressed transcripts in jute upon fungal infection and beta-amino butyric acid treatment. Physiol Mol Plant Physiol 76: 59-66.
Ghosh, A., Hartung, S., van der Does, C., Tainer, J.A., and Albers, S.V. (2011) Archaeal flagellar ATPase motor shows ATP-dependent hexameric assembly and activity stimulation by specific lipid binding. Biochem J 437: 43-52.
Pohlschroder, M., Ghosh, A., Tripepi, M., and Albers, S.V. (2011) Archaeal type IV pilus-like structures-evolutionarily conserved prokaryotic surface organelles. Curr Opin Microbiol 14: 357-363.
Ghosh, A., and Albers, S.V. (2011) Assembly and function of the archaeal flagellum. Biochem Soc Trans 39: 64-69.
Basu, S., Roy, A., Ghosh, A., Bera, A., Chattopadhyay, D., and Chakrabarti, K. (2011) Arg(235) is an essential catalytic residue of Bacillus pumilus DKS1 pectate lyase to degum ramie fibre. Biodegradation 22: 153-161.
Ghosh, A., Dey, N., Bera, A., Tiwari, A., Sathyaniranjan, K., Chakrabarti, K., and Chattopadhyay, D. (2010) Culture independent molecular analysis of bacterial communities in the mangrove sediment of Sundarban, India. Saline Systems 6:1.
Ghosh, A., Chakrabarti, K., and Chattopadhyay, D. (2009) Cloning of feather-degrading minor extracellular protease from Bacillus cereus DCUW: dissection of the structural domains. Microbiology 155: 2049-2057.
Barua, S., Tripathi, S., Ghosh, A., Chakraborty, A., Ghosh, S., and Chakrabarti, K. (2008) Studies on Non-symbiotic Diazotropic Bacterial Population of the saline Soils of Sundarbans. J Pure Appl Microbiol 2: 355-364.
Ghosh, A., Chakrabarti, K., and Chattopadhyay, D. (2008) Degradation of raw feather by a novel high molecular weight extracellular protease from newly isolated Bacillus cereus DCUW. J Ind Microbiol Biotechnol 35: 825-834.
Basu, S., Ghosh, A., Bera, A., Saha, M.N., Chattopadhyay, D., and Chakrabarti, K. (2008) Thermodynamic characterization of a highly thermoactive extracellular pectate lyase from a new isolate Bacillus pumilus DKS1. Bioresource Technology 99: 8088-8094.
Sinan, M., Panda, M., Ghosh, A., Dhara, K., Fanwick, P.E., Chattopadhyay, D.J., and Goswami, S. (2008) Mild synthesis of a family of planar triazinium cations via proton-assisted cyclization of pyridyl containing azo compounds and studies on DNA intercalation. J American Chem Soc 130: 5185-5193.
Saha, B., Singh, A.K., Ghosh, A., and Bal, M. (2008) Identification and characterization of a vancomycin-resistant Staphylococcus aureus isolated from Kolkata (South Asia). J Med Microbiol 57: 72-79.
Ghosh, A., Basu, S., Datta, H., and Chattopadhyay, D. (2007) Evaluation of polymerase chain reaction-based ribosomal DNA Sequencing technique for the diagnosis of mycotic keratitis. Am J Ophthalmol 144: 396-403.
Ghosh, A., Maity, B., Chakrabarti, K., and Chattopadhyay, D. (2007) Bacterial diversity of east calcutta wet land area: Possible identification of potential bacterial population for different biotechnological uses. Microb Ecol 54: 452-459.
- Recipient of Carl Storm International Diversity Fellowship for attending the Gordon Research Conferences: Structural, Functional, and Evolutionary Genomics at Wellcome Trust Conference Centre, Hinxton, Cambridge, United Kingdom, 2007
- Recipient of FEMS Congress Grant for Young Scientists from Federation of European Microbiological Society (FEMS) at the 4th FEMS Congress of European Microbiologists at PALEXPO, Geneva, Switzerland, 2011
- Recipient of Max Planck Postdoctoral Fellowship , 2008-2012
- Selected as UGC-Assistant Professor through UGC-Faculty Recharge Program (UGC-FRP) by University Grant Commission (UGC), 2012
- Selected as the Ramanujan Fellow by Department of Science and Technology (DST), India, 2013
- Recipient of DST-Fast Track Scheme for Young Scientists, 2014
- Recipient of EMBO travel grant to attend EMBO workshop on “Molecular biology of archaea: From mechanisms to ecology” at the University of Vienna, Austria, 2018
Bose Institute (MSc--‐PhD): Biophysical techniques (Chromatography), Prokaryotic Molecular Biology, Microbial Nutrition (Methanogenesis); WBUT, Kolkata (M Tech/M Sc-PhD): Microbial Nutrition, Cell Biology; Jogamaya Devi College, Calcutta University (M Sc): Genomics and proteomics; Bose Institute, Kolkata (PhD coursework): Introduction to Electron Microscopy.
|Arghya Bhowmick||Junior Research Fellow||Biochemistry||Centenary||25693235||arghyabhowmick|
|Chandrima Bhattacharyya||Senior Research Fellow||Biochemistry||Centenary||25693225||chandrima|
|Sayandeep Gupta||Senior Research Fellow||Biochemistry||Centenary||25693225||sdgupta|
|Shayantan Mukherji||Senior Research Fellow||Biochemistry||Centenary||25693225||shayantan|
- Chandrima Bhattacharyya (INSPIRE Fellow-Adhoc)
- Shayantan Mukherji (UGC-Adhoc)
- Mausam Roy (UGC-Adhoc)
- Sayandeep Gupta (CSIR-SRF Adhoc)
- Arghya Bhowmick (CSIR-Adhoc)
- Koustav Bhakta (Institute Fellow)
- Rupsa Roy (CSIR-Adhoc)
1. Dr. Ivy Mallick (WB DBT-SRA; 2015-2016)
2. Dr. Somi Patranabis (DBT Postdoctoral Fellow)
3. Dhritiman Dey (WB DBT-Project Fellow 2016-2017)
- 02/11/2018: Congratulations to Ms Chandrima Bhattacharya for getting selected for the prestigious Newton Bhabha Fellowship 2018-2019- an Indo-UK exchange program for PhD.
- 05/10/2018: We welcome Ms. Rupsa Roy as part of our research group. We wish her the best during her period of stay with us.
- 05/09/2018: Congratulations to the Biochemistry team on the successful publication of their first research paper: “The oligomeric plasticity of Hsp20 of Sulfolobus acidocaldarius protects environment-induced protein aggregation and membrane destabilization.” BBA-Biomembranes, Dec 2018. Special congratulations to Mr. Mousam Roy, our first author!! (https://doi.org/10.1016/j.bbamem.2018.09.005)
- 14/08/2018: MONGABAY India has showcased our recent findings on environmental antibiotic resistance in environment under the title “Sundarbans mangroves harbour antibiotic resistant bacteria”. (https://india.mongabay.com/2018/08/14/sundarbans-mangroves-harbour-antibiotic-resistant-bacteria/)
- 14/08/2018: We welcome Mr. Koustav Bhakta as part of our research group. We wish him the best during his period of stay with us.
- 03/08/2018: Congratulations to the environmental microbiology group especially to Mr. Anish Bhattacharyya on the successful publication of his paper: “Anthropogenic influence shapes the distribution of antibiotic resistant bacteria in the sediment of Sundarban estuary in India” Science of the Total Environment, Jan 2019. (https://doi.org/10.1016/j.scitotenv.2018.08.038)
- 01/06/2018: Congratulations Mr. Sayandeep Gupta on being successfully selected as a CSIR-SRF adhoc by CSIR, Govt. of India.
- 12/03/2018-15/3/2018: Congratulations Ms. Chandrima Bhattacharyya for being selected and for attending the 10th HOPE meeting organized by JSPS, held in Yokohama, Japan.
- 12/02/2018: MONGABAY India has showcased our recent findings on Heavy metal bioremediation by halotolerant PGPR isolates under the title “Bioremediation boost: Sundarbans mangroves shelter arsenic loving, salt tolerant bacteria. (https://india.mongabay.com/2018/02/12/bioremediation-boost-sundarbans-mangroves-shelter-arsenic-loving-salt-tolerant-bacteria/)
- 01/01/2018: Congratulations to the environmental microbiology group especially to Ms. Ivy Mallick on the successful publication of her paper: “Effective rhizoinoculation and biofilm formation by arsenic immobilizing halophilic plant growth promoting bacteria (PGPB) isolated from mangrove rhizosphere: A step towards arsenic rhizoremediation” in Science of the Total Environment, Jan 2018. (https://doi.org/10.1016/j.scitotenv.2017.07.234)
- 15/12/2017: We welcome Mr. Arghya Bhowmick as part of our research group. We wish him the best during his period of stay with us
- 21/03/2017: 01/01/2018: Congratulations to the environmental microbiology group especially to Ms. Chandrima Bhattacharyya on the successful publication of her paper: “Genome-Guided Insights into the Plant Growth Promotion Capabilities of the Physiologically Versatile Bacillus aryabhattai Strain AB211” in Frontiers in Microbiology, March 2017. (https://doi.org/10.3389/fmicb.2017.00411)